The impact of exertional-heat stress on gastrointestinal integrity, gastrointestinal symptoms, systemic endotoxin and cytokine profile

Purpose The study aimed to determine the effects of exertional-heat stress on gastrointestinal integrity, symptoms, systemic endotoxin and inflammatory responses; and assess the relationship between changes in body temperature and gastrointestinal perturbations. Methods Ten endurance runners complet...

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Bibliographic Details
Published in:European journal of applied physiology 2018-02, Vol.118 (2), p.389-400
Main Authors: Snipe, Rhiannon M. J., Khoo, Anthony, Kitic, Cecilia M., Gibson, Peter R., Costa, Ricardo J. S.
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Body temperature
Cortisol
Cytokines
Epithelium
Fatty acid-binding protein
Heat
Heat stress
Hormones
Human Physiology
Inflammation
Interleukin 10
Intestine
L-Rhamnose
Lactulose
Nausea
Occupational Medicine/Industrial Medicine
Original Article
Permeability
Physical training
Rhamnose
Sports Medicine
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Summary:Purpose The study aimed to determine the effects of exertional-heat stress on gastrointestinal integrity, symptoms, systemic endotoxin and inflammatory responses; and assess the relationship between changes in body temperature and gastrointestinal perturbations. Methods Ten endurance runners completed 2 h running at 60% V ˙ O 2max in hot (HOT: 35 °C) and temperate (TEMP: 22 °C)-ambient conditions. Rectal temperature ( T re ) and gastrointestinal symptoms were recorded every 10 min during exercise. Blood samples were collected pre- and post-exercise, and during recovery to determine plasma intestinal fatty acid binding protein (I-FABP), cortisol, bacterial endotoxin and cytokine profile. Calprotectin was determined from pre- and post-exercise faecal samples. Urinary lactulose: l -rhamnose ratio was used to measure intestinal permeability. Results Compared with TEMP, HOT significantly increased T re (1.4 ± 0.5 vs 2.4 ± 0.8 °C, p  
ISSN:1439-6319
1439-6327
DOI:10.1007/s00421-017-3781-z