Ultrasound-based logistic regression model LR2 versus magnetic resonance imaging for discriminating between benign and malignant adnexal masses: a prospective study

Background The diagnostic performances of the International Ovarian Tumor Analysis (IOTA) ultrasound-based logistic regression model (LR2) and magnetic resonance imaging (MRI) in discriminating between benign and malignant adnexal masses have not been directly compared in a single study. Methods Usi...

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Published in:International journal of clinical oncology 2018-06, Vol.23 (3), p.514-521
Main Authors: Shimada, Kanane, Matsumoto, Koji, Mimura, Takashi, Ishikawa, Tetsuya, Munechika, Jiro, Ohgiya, Yoshimitsu, Kushima, Miki, Hirose, Yusuke, Asami, Yuka, Iitsuka, Chiaki, Miyamoto, Shingo, Onuki, Mamiko, Tsunoda, Hajime, Matsuoka, Ryu, Ichizuka, Kiyotake, Sekizawa, Akihiko
Format: Article
Language:English
Subjects:
Benign
Cancer Research
Magnetic resonance imaging
Medicine
Medicine & Public Health
Metastases
NMR
Nuclear magnetic resonance
Oncology
Original Article
Ovarian cancer
Surgical Oncology
Tumors
Ultrasonic imaging
Ultrasound
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Summary:Background The diagnostic performances of the International Ovarian Tumor Analysis (IOTA) ultrasound-based logistic regression model (LR2) and magnetic resonance imaging (MRI) in discriminating between benign and malignant adnexal masses have not been directly compared in a single study. Methods Using the IOTA LR2 model and subjective interpretation of MRI findings by experienced radiologists, 265 consecutive patients with adnexal masses were preoperatively evaluated in two hospitals between February 2014 and December 2015. Definitive histological diagnosis of excised tissues was used as a gold standard. Results From the 265 study subjects, 54 (20.4%) tumors were histologically diagnosed as malignant (including 11 borderline and 3 metastatic tumors). Preoperative diagnoses of malignant tumors showed 91.7% total agreement between IOTA LR2 and MRI, with a kappa value of 0.77 [95% confidence interval (CI), 0.68–0.86]. Sensitivity of IOTA LR2 (0.94, 95% CI, 0.85–0.98) for predicting malignant tumors was similar to that of MRI (0.96, 95% CI, 0.87–0.99; P  = 0.99), whereas specificity of IOTA LR2 (0.98, 95% CI, 0.95–0.99) was significantly higher than that of MRI (0.91, 95% CI, 0.87–0.95; P  = 0.002). Combined IOTA LR2 and MRI results gave the greatest sensitivity (1.00, 95% CI, 0.93–1.00) and had similar specificity (0.91, 95% CI, 0.86–0.94) to MRI. Conclusions The IOTA LR2 model had a similar sensitivity to MRI for discriminating between benign and malignant tumors and a higher specificity compared with MRI. Our findings suggest that the IOTA LR2 model, either alone or in conjunction with MRI, should be included in preoperative evaluation of adnexal masses.
ISSN:1341-9625
1437-7772
DOI:10.1007/s10147-017-1222-y