Potential influence of the phthalates on normal liver function and cardiometabolic risk in males

Phthalates are ubiquitous environmental contaminants, massively used in industry as plasticizers and additives in cosmetics, which may impair the human endocrine system inducing fertility problems, respiratory diseases, obesity, and neuropsychological disorders. The aim of this study was to examine...

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Bibliographic Details
Published in:Environmental monitoring and assessment 2018-01, Vol.190 (1), p.17-17, Article 17
Main Authors: Milošević, Nataša, Milić, Nataša, Živanović Bosić, Dragana, Bajkin, Ivana, Perčić, Ivanka, Abenavoli, Ludovico, Medić Stojanoska, Milica
Format: Article
Language:English
Subjects:
Additives
Adipose tissue
Adolescent
Adult
Atmospheric Protection/Air Quality Control/Air Pollution
Biomarkers - urine
Body mass
Body Mass Index
Body size
Body weight
Cardiovascular Diseases - metabolism
Cardiovascular Diseases - urine
Cholesterol
Contaminants
Correlation
Cosmetics
Cross-Sectional Studies
Diethylhexyl Phthalate - analogs & derivatives
Diethylhexyl Phthalate - toxicity
Diethylhexyl Phthalate - urine
Earth and Environmental Science
Ecology
Ecotoxicology
Endocrine Disruptors - toxicity
Endocrine Disruptors - urine
Endocrine system
Environment
Environmental Exposure - analysis
Environmental Management
Environmental monitoring
Environmental science
Exposure
Fertility
Health risks
High density lipoprotein
Humans
Insulin
Insulin resistance
Lipids
Lipoproteins
Liver
Liver - drug effects
Liver - metabolism
Liver Function Tests
Male
Males
Metabolites
Middle Aged
Monitoring/Environmental Analysis
Obesity
Obesity - metabolism
Obesity - urine
Overweight
Phthalate esters
Phthalates
Phthalic Acids - toxicity
Phthalic Acids - urine
Plasticizers
Respiratory diseases
Respiratory disorders
Risk
Risk analysis
Risk factors
Samples
Serum
Serum levels
Statistical analysis
Statistical methods
Statistical significance
Transaminase
Urine
Weight
Young Adult
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Summary:Phthalates are ubiquitous environmental contaminants, massively used in industry as plasticizers and additives in cosmetics, which may impair the human endocrine system inducing fertility problems, respiratory diseases, obesity, and neuropsychological disorders. The aim of this study was to examine the influence of the monoethyl phthalate (MEP) and mono-(2-ethylhexyl) phthalate (MEHP) on the liver function and cardiometabolic risk factors in males. In this research, 102 male participants (51 normal weight and 51 overweight/obese) were enrolled and examined for phthalate metabolites exposure in urine samples after 12 h of fasting. MEP was found in 28.43% (29/102) volunteers, while MEHP was detected among 20.59% (21/102) participants. Statistically significant increment in transaminase serum levels was observed in MEP-positive normal weight subgroup. Linear correlation was obtained between MEP concentration in urine samples and triglyceride (TG) serum levels ( r 2  = 0.33; p  
ISSN:0167-6369
1573-2959
DOI:10.1007/s10661-017-6398-0