Multi-modal imaging investigation of anterior cingulate cortex cytoarchitecture in neurodevelopment

Multi-modal imaging may improve our understanding of the relationship between cortical morphology and cytoarchitecture. To this end we integrated the analyses of several magnetic resonance imaging (MRI) and spectroscopy (MRS) metrics within the anterior cingulate cortex (ACC). Considering the ACCs r...

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Bibliographic Details
Published in:European neuropsychopharmacology 2018-01, Vol.28 (1), p.13-23
Main Authors: Forde, Natalie J., Naaijen, Jilly, Lythgoe, David J., Akkermans, Sophie E.A., Openneer, Thaïra J.C., Dietrich, Andrea, Zwiers, Marcel P., Hoekstra, Pieter J., Buitelaar, Jan K.
Format: Article
Language:English
Subjects:
ACC
Child
Cytoarchitecture
Diffusion Magnetic Resonance Imaging
Diffusion MRI
Female
Gyrus Cinguli - anatomy & histology
Gyrus Cinguli - diagnostic imaging
Gyrus Cinguli - growth & development
Gyrus Cinguli - metabolism
Humans
Male
MRS
Multimodal Imaging
Neurodevelopment
Neurodevelopmental Disorders - diagnostic imaging
Neurodevelopmental Disorders - metabolism
Neurodevelopmental Disorders - pathology
Proton Magnetic Resonance Spectroscopy
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Summary:Multi-modal imaging may improve our understanding of the relationship between cortical morphology and cytoarchitecture. To this end we integrated the analyses of several magnetic resonance imaging (MRI) and spectroscopy (MRS) metrics within the anterior cingulate cortex (ACC). Considering the ACCs role in neurodevelopmental disorders, we also investigated the association between neuropsychiatric symptoms and the various metrics. T1 and diffusion-weighted MRI and 1H-MRS (ACC voxel) data along with phenotypic information were acquired from children (8–12 years) with various neurodevelopmental disorders (n=95) and healthy controls (n=50). From within the MRS voxel mean diffusivity (MD) of the grey matter fraction, intrinsic curvature (IC) of the surface and concentrations of creatine, choline, glutamate, N-acetylaspartate and myo-inositol were extracted. Linear models were used to investigate if the neurochemicals predicted MD and IC or if MD predicted IC. Finally, measures of various symptom severities were included to determine the influence of symptoms of neurodevelopmental disorders. All five neurochemicals inversely predicted MD (all puncorrected0.05). Severity of autism symptoms related positively to MD (puncorrected=0.002, β=0.39). Our findings support the notion that the neurochemicals relate to cytoarchitecture within the cortex. Additionally, we showed that autism symptoms across participants relate to the ACC cytoarchitecture.
ISSN:0924-977X
1873-7862
DOI:10.1016/j.euroneuro.2017.11.021