Clastogenicity and aneuploidy in newborn and adult mice exposed to 50 Hz magnetic fields

Purpose: To detect possible clastogenic and aneugenic properties of a 50 Hz, 650 μT magnetic field. Materials and methods: The micronucleus test with CREST (Calcinosis, Raynaud's phenomenon, Esophageal dismotility, Sclerodactility, Telangectasia) antibody staining was performed on liver and per...

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Bibliographic Details
Published in:International journal of radiation biology 2006-08, Vol.82 (8), p.561-567
Main Authors: Udroiu, I., Cristaldi, M., Ieradi, L. A., Bedini, A., Giuliani, L., Tanzarella, C.
Format: Article
Language:English
Subjects:
Aneuploidy
Animals
Animals, Newborn
CREST
Electromagnetic Fields - adverse effects
ELF
Environmental Exposure - adverse effects
Female
genotoxicity
Magnetic fields
Mice
micronuclei
Mutation - radiation effects
Pregnancy
Prenatal Exposure Delayed Effects - etiology
Prenatal Exposure Delayed Effects - genetics
Radiation Dosage
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Summary:Purpose: To detect possible clastogenic and aneugenic properties of a 50 Hz, 650 μT magnetic field. Materials and methods: The micronucleus test with CREST (Calcinosis, Raynaud's phenomenon, Esophageal dismotility, Sclerodactility, Telangectasia) antibody staining was performed on liver and peripheral blood sampled from newborn mice exposed to an ELF (Extremely Low Frequency) magnetic field during the whole intra-uterine life (21 days), and on bone marrow and peripheral blood sampled from adult mice exposed to the same magnetic field for the same period. Results: Data obtained in newborn mice show a significant increase in micronuclei frequencies. In absolute terms, most of the induced micronuclei were CREST-negative (i.e., formed by a chromosome fragment). However, in relative terms, ELF exposure caused a two-fold increase in CREST-negative micronuclei and a four-fold increase in CREST-positive micronuclei (i.e., formed by a whole chromosome). No significant effect was recorded on exposed adults. Conclusions: These findings suggest the need for investigation of aneugenic properties of ELF magnetic fields in order to establish a possible relationship to carcinogenesis.
ISSN:0955-3002
1362-3095
DOI:10.1080/09553000600876660