Photo-induced toxicity of tungsten oxide photochromic nanoparticles

We synthesised a new type of photochromic tungsten oxide nanoparticles, analysed their photocatalytic activity and carried out a thorough analysis of their effect on prokaryotic and eukaryotic organisms. Ultrasmall hydrated tungsten oxide nanoparticles were prepared by means of hydrothermal treatmen...

Full description

Saved in:
Bibliographic Details
Published in:Journal of photochemistry and photobiology. B, Biology Biology, 2018-01, Vol.178, p.395-403
Main Authors: Popov, A.L., Zholobak, N.M., Balko, O.I., Balko, O.B., Shcherbakov, A.B., Popova, N.R., Ivanova, O.S., Baranchikov, A.E., Ivanov, V.K.
Format: Article
Language:English
Subjects:
Apoptosis
Biocompatibility
Biomedical materials
Catalytic activity
Cation exchange
Cation exchanging
Chemical synthesis
Daylight
Discoloration
E coli
Embryo fibroblasts
Fibroblasts
Fungi
Household appliances
Hydrothermal treatment
Indigo
Irradiation
Mammalian cells
Nanoparticles
Photobiology
Photocatalysis
Photochromism
Phototoxicity
Polyvinylpyrrolidone
Sodium
Sodium tungstate
Toxicity
Tungsten
Tungsten oxide
Tungsten oxides
Tungstic acid
Ultraviolet radiation
UV irradiation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We synthesised a new type of photochromic tungsten oxide nanoparticles, analysed their photocatalytic activity and carried out a thorough analysis of their effect on prokaryotic and eukaryotic organisms. Ultrasmall hydrated tungsten oxide nanoparticles were prepared by means of hydrothermal treatment of tungstic acid in the presence of polyvinylpyrrolidone as a template, stabiliser and growth regulator. Tungstic acid was synthesised through an ion-exchange method using sodium tungstate solution and a strongly acidic cation exchange resin. Upon illumination, photochromic nanoparticles of WO3 were shown to increase greatly their toxicity against both bacterial (both gram-positive and gram-negative – P. aeruginosa, E. coli and S. aureus) and mammalian cells (primary mouse embryonic fibroblasts); under the same conditions, fungi (C. albicans) were less sensitive to the action of tungsten oxide nanoparticles. UV irradiation of primary mouse fibroblasts in the presence of WO3 nanoparticles demonstrated a time- and dose-dependent toxic effect, the latter leading to a significant decrease in dehydrogenase activity and an increase in the number of dead cells. WO3 nanoparticles were photocatalytically active under both UV light and even diffused daylight filtered through a window glass, leading to indigo carmine organic dye discolouration. The obtained experimental data not only show good prospects for biomedical applications of tungsten trioxide, but also demonstrate the need for clear control of biosafety when it is used in various household materials and appliances. [Display omitted] •Photochromic WO3 nanoparticles were synthesised using ion-exchange method.•UV increased toxicity of WO3 nanoparticles against bacterial and mammalian cells.•WO3 nanoparticles were photocatalytically active under UV-illumination.
ISSN:1011-1344
1873-2682
DOI:10.1016/j.jphotobiol.2017.11.021