Increased glutamate receptor gene expression in the cerebral cortex of insulin induced hypoglycemic and streptozotocin-induced diabetic rats

Abstract Hypoglycemia causes brain fuel deprivation, resulting in functional brain failure and brain death. It is a serious complication of insulin therapy in diabetic patients. A single intrafemoral dose of streptozotocin was administered to induce diabetes. Hypoglycemia was induced by appropriate...

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Bibliographic Details
Published in:Neuroscience 2008-10, Vol.156 (2), p.298-304
Main Authors: Joseph, A, Antony, S, Paulose, C.S
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
Biological and medical sciences
Blood Glucose - metabolism
cerebral cortex
Cerebral Cortex - metabolism
Diabetes Mellitus, Experimental - pathology
Diabetes. Impaired glucose tolerance
Disease Models, Animal
Dizocilpine Maleate - metabolism
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Excitatory Amino Acid Antagonists - metabolism
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation - drug effects
Gene Expression Regulation - physiology
glutamate excitotoxicity
Glutamic Acid - metabolism
hypoglycemia
Hypoglycemia - chemically induced
Hypoglycemia - pathology
Insulin
Male
Medical sciences
mGluR5
Neurology
NMDA2B
Protein Binding - drug effects
Radioligand Assay
Rats
Rats, Wistar
Receptors, Glutamate - classification
Receptors, Glutamate - genetics
Receptors, Glutamate - metabolism
RNA, Messenger - metabolism
Tritium - metabolism
Vertebrates: nervous system and sense organs
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Summary:Abstract Hypoglycemia causes brain fuel deprivation, resulting in functional brain failure and brain death. It is a serious complication of insulin therapy in diabetic patients. A single intrafemoral dose of streptozotocin was administered to induce diabetes. Hypoglycemia was induced by appropriate doses of insulin s.c. in control and diabetic rats. Glutamate content and glutamate receptor kinetics were studied using [3 H]glutamate. [3 H]MK 801 was used to study the NMDA receptor kinetics. NMDA2B and metabotropic glutamate receptor (mGluR) 5 subunits receptor gene expressions were done using real time PCR. There was a significant ( P
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2008.07.022