Associations of neurofunctional, morphometric and metabolic abnormalities with clinical symptom severity and recognition deficit in obsessive–compulsive disorder

Obsessive–compulsive disorder (OCD) causes neural dysfunction associated with cognitive deficit and emotional dysregulation. This study assessed the associations of the neurofunctional changes, gray matter (GM) and white matter (WM) volume alterations in conjunction with in vivo metabolic changes on...

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Bibliographic Details
Published in:Journal of affective disorders 2018-02, Vol.227, p.603-612
Main Authors: Moon, Chung-Man, Jeong, Gwang-Woo
Format: Article
Language:English
Subjects:
Adult
Aspartic Acid - analogs & derivatives
Aspartic Acid - metabolism
Brain - anatomy & histology
Brain - metabolism
Brain Mapping - methods
Case-Control Studies
Choline - metabolism
Creatine - metabolism
Event-related fMRI
Female
Glutamic Acid - metabolism
Humans
Magnetic Resonance Imaging
Male
Memory, Short-Term - physiology
Obsessive-Compulsive Disorder - metabolism
Obsessive-Compulsive Disorder - pathology
Obsessive–compulsive disorder
Proton Magnetic Resonance Spectroscopy
Voxel-based morphometry
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Summary:Obsessive–compulsive disorder (OCD) causes neural dysfunction associated with cognitive deficit and emotional dysregulation. This study assessed the associations of the neurofunctional changes, gray matter (GM) and white matter (WM) volume alterations in conjunction with in vivo metabolic changes on the working memory tasks in patients with OCD. Eighteen patients with OCD and 18 healthy controls matched for age, sex, and educational levels underwent high-resolution T1-weighted magnetic resonance imaging (MRI), event-related functional MRI (fMRI), and proton magnetic resonance spectroscopy (1H-MRS) at 3T. In fMRI, patients with OCD showed lower activities in the cerebellum, inferior temporal gyrus, orbitofrontal gyrus, dorsolateral prefrontal cortex and calcarine gyrus compared to the controls. In VBM, the patients showed significantly reduced GM volumes, especially in the cerebellum, hippocampus, and superior temporal gyrus, together with significantly reduced WM volumes in the retrolenticular part of the internal capsule, dorsolateral prefrontal cortex (DLPFC) and orbitofrontal gyrus. In 1H-MRS, the ratios of N-acetylaspartate/creatine and choline/creatine were significantly lower in the DLPFC of the patients than in the controls, whereas the ratio of β∙γ-glutamine-glutamate/creatine was significantly higher in the patients than in the controls. This study examined small numbers of subjects in each one of the groups. The findings will be helpful to aid us in understanding of neurocognitive impairment in OCD, and thus, enhancing the diagnostic accuracy for OCD by additional information on the associated brain functional deficit, cerebral volume change and metabolic abnormality. •The BOLD signal change and Cho/Cr ratio in the DLPFC were positively correlated with the accuracy.•The WM volume of the DLPFC was positively correlated with NAA/Cr ratio.•The WM volume of the DLPFC was negatively correlated with β∙γ-Glx/Cr ratio.•BOLD signal and WM volume changes in the DLPFC were negatively correlated with Y-BOCS scores.
ISSN:0165-0327
1573-2517
DOI:10.1016/j.jad.2017.11.059