Repeated administration of diphenyl diselenide to pregnant rats induces adverse effects on embryonic/fetal development

The present study was carried out to investigate the effects of diphenyl diselenide, (PhSe) 2, on embryo-fetal development. Dams were treated subcutaneously with 1.5, 3.0 and 6.0 mg/kg (PhSe) 2 from days 6 to 15 of pregnancy. After cesarean section at gestation day (GD) 20, external and skeletal abn...

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Bibliographic Details
Published in:Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2007-02, Vol.23 (2), p.175-181
Main Authors: Weis, Simone N., Favero, Alexandre M., Stangherlin, Eluza C., Manarin, Flavia G., Rocha, Joao B.T., Nogueira, Cristina W., Zeni, Gilson
Format: Article
Language:English
Subjects:
Abnormalities, Drug-Induced
Animals
Benzene Derivatives - toxicity
Biological and medical sciences
Bone and Bones - drug effects
Crown-Rump Length
Diphenyl diselenide
Dose-Response Relationship, Drug
Embryology: invertebrates and vertebrates. Teratology
Embryonic Development - drug effects
Female
Fetal development
Fetal Development - drug effects
Fetal Growth Retardation
Fetal Weight - drug effects
Fundamental and applied biological sciences. Psychology
Growth retardation
Injections, Subcutaneous
Maternal Exposure
Medical sciences
Organoselenium Compounds - toxicity
Placenta - drug effects
Placenta - pathology
Pregnancy
Rats
Rats, Wistar
Selenium
Teratogens - classification
Teratogens - toxicity
Teratology. Teratogens
Toxicity
Toxicology
Weight Gain - drug effects
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Summary:The present study was carried out to investigate the effects of diphenyl diselenide, (PhSe) 2, on embryo-fetal development. Dams were treated subcutaneously with 1.5, 3.0 and 6.0 mg/kg (PhSe) 2 from days 6 to 15 of pregnancy. After cesarean section at gestation day (GD) 20, external and skeletal abnormalities were evaluated. A decrease in maternal body weight gain was found in (PhSe) 2 groups, indicating maternal toxicity. There was a reduction in the fetal weight and in crown-rump (CR) length of fetuses at three doses tested. The occipito-nasal length decreased in fetuses from dams exposed to 3.0 mg/kg (PhSe) 2. Signs of delayed ossification in the skull, sternebrae and limbs were observed in all (PhSe) 2 groups, revealing a relation between morphological alterations and growth retardation in fetuses, but none of the changes appeared to be dose-dependent. Exposure of dams to (PhSe) 2 resulted in altered placental morphology that may have contributed to adverse reproductive outcomes. We concluded that (PhSe) 2 is toxic to dams and induces developmental delay of the fetal skeleton, but does not cause externally visible malformations in rat fetuses, in this experimental procedure.
ISSN:0890-6238
1873-1708
DOI:10.1016/j.reprotox.2006.09.008