Responsive polymers in controlled drug delivery

This article reviews the state-of-the art in responsive polymer systems for controlled drug delivery applications. The paper describes different types of stimuli-sensitive systems and gives an account of their synthesis through methods such as group transfer polymerization, atom transfer radical pol...

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Bibliographic Details
Published in:Progress in polymer science 2008-11, Vol.33 (11), p.1088-1118
Main Authors: Bajpai, A.K., Shukla, Sandeep K., Bhanu, Smitha, Kankane, Sanjana
Format: Article
Language:English
Subjects:
Applied sciences
Biological and medical sciences
Drug delivery
Exact sciences and technology
General pharmacology
Hydrogels
Medical sciences
Organic polymers
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Physicochemistry of polymers
Properties and characterization
Responsive polymers
Solution and gel properties
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Summary:This article reviews the state-of-the art in responsive polymer systems for controlled drug delivery applications. The paper describes different types of stimuli-sensitive systems and gives an account of their synthesis through methods such as group transfer polymerization, atom transfer radical polymerization and reversible addition-fragmentation chain transfer polymerization. The article also discusses classification of various drug delivery systems: diffusion controlled systems, chemically controlled systems, swelling-controlled systems and modulated release systems. A survey of the recent literature on various stimuli-responsive polymer hydrogels in controlled drug delivery is also included.
ISSN:0079-6700
1873-1619
DOI:10.1016/j.progpolymsci.2008.07.005