Birth Defects Associated With Congenital Zika Virus Infection in Mexico

Part of the work agenda of international health authorities is to define the clinical spectrum of the congenital Zika syndrome (CZS) in different territories. We describe the clinical variability that gave rise to the suspicion of CZS in 3 newborn patients in the south of Mexico with active transmis...

Full description

Saved in:
Bibliographic Details
Published in:Clinical pediatrics 2018-07, Vol.57 (8), p.927-936
Main Authors: Contreras-Capetillo, Silvina Noemí, Valadéz-González, Nina, Manrique-Saide, Pablo, Carcaño-Castillo, Rafael Eduardo, Pacheco-Tugores, Freddy, Barrera-Pérez, Hirian Alonso Moshe, Pinto-Escalante, Doris, Lliteras-Cardín, Manuel, Hoil-Parra, José Alfredo, Cáceres-Solís, José Luis, Pavía-Ruz, Norma
Format: Article
Language:English
Subjects:
Arthrogryposis
Birth
Birth defects
Congenital defects
DNA-directed RNA polymerase
Enzyme-linked immunosorbent assay
Health risk assessment
Immunoglobulin M
Infections
Polymerase chain reaction
Pregnancy
Reverse transcription
Ribonucleic acid
RNA
Variability
Vector-borne diseases
Viremia
Viruses
Zika virus
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Part of the work agenda of international health authorities is to define the clinical spectrum of the congenital Zika syndrome (CZS) in different territories. We describe the clinical variability that gave rise to the suspicion of CZS in 3 newborn patients in the south of Mexico with active transmission of Zika. All of them presented Zika RNA by reverse transcription–polymerase chain reaction and positive antibodies for IgM by enzyme-linked immunosorbent assay. None of the mothers tested positive for active viremia, only one mother had Zika-symptoms and titers of Zika-positive IgM. Intrauterine growth restriction, brain disruption sequence, and intracranial calcifications are the clinical characteristics common in all. One patient had neural tube defect and other, arthrogryposis. Because the majority of pregnant women will be asymptomatic to Zika, we must be alert to the clinical variability of the birth defects associated to pregnancy Zika infection. Reports of clinical cases encourage the medical community to make diagnostic decisions.
ISSN:0009-9228
1938-2707
DOI:10.1177/0009922817738341