A lower eicosapentaenoic acid/arachidonic acid ratio is associated with in-hospital fatal arrhythmic events in patients with acute myocardial infarction: a J-MINUET substudy

The ratio of serum eicosapentaenoic acid (EPA) to arachidonic acid (AA) is significantly associated with long-term clinical outcomes in patients with acute myocardial infarction (AMI). However, it has not been conclusively demonstrated that higher serum EPA/AA ratio fares better clinical outcomes in...

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Published in:Heart and vessels 2018-05, Vol.33 (5), p.481-488
Main Authors: Hashimoto, Takuya, Ako, Junya, Nakao, Koichi, Ozaki, Yukio, Kimura, Kazuo, Noguchi, Teruo, Yasuda, Satoshi, Suwa, Satoru, Fujimoto, Kazuteru, Nakama, Yasuharu, Morita, Takashi, Shimizu, Wataru, Saito, Yoshihiko, Hirohata, Atsushi, Morita, Yasuhiro, Inoue, Teruo, Okamura, Atsunori, Uematsu, Masaaki, Hirata, Kazuhito, Tanabe, Kengo, Shibata, Yoshisato, Owa, Mafumi, Tsujita, Kenichi, Funayama, Hiroshi, Kokubu, Nobuaki, Kozuma, Ken, Uemura, Shirou, Toubaru, Tetsuya, Saku, Keijirou, Ohshima, Shigeru, Nakai, Michikazu, Nishimura, Kunihiro, Miyamoto, Yoshihiro, Ogawa, Hisao, Ishihara, Masaharu
Format: Article
Language:English
Subjects:
Acids
Arachidonic acid
Biomedical Engineering and Bioengineering
Bleeding
Cardiac arrhythmia
Cardiac Surgery
Cardiology
Clinical outcomes
Eicosapentaenoic acid
Electrocardiography
Fibrillation
Health care facilities
Heart
Heart attacks
Heart diseases
Incidence
Institutions
Medicine
Medicine & Public Health
Mortality
Myocardial infarction
Original Article
Patients
Tachycardia
Vascular Surgery
Ventricle
Ventricular fibrillation
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Summary:The ratio of serum eicosapentaenoic acid (EPA) to arachidonic acid (AA) is significantly associated with long-term clinical outcomes in patients with acute myocardial infarction (AMI). However, it has not been conclusively demonstrated that higher serum EPA/AA ratio fares better clinical outcomes in the early phase of AMI. The Japanese registry of acute Myocardial INfarction diagnosed by Universal dEfiniTion (J-MINUET) is a prospective multicenter registry conducted in 28 Japanese medical institutions between July 2012 and March 2014. We enrolled 3,283 consecutive AMI patients who were admitted to participating institutions within 48 h of symptom onset. A serum EPA/AA ratio was available for 629 of these patients. The endpoints were in-hospital mortality and major adverse cardiac events (MACE), defined as a composite of all cause death, cardiac failure, ventricular tachycardia (VT) and/or ventricular fibrillation (VF) and bleeding during hospitalization. Although similar rates of in-hospital mortality, cardiac failure, bleeding, and MACE were found in the lower serum EPA/AA group and higher serum EPA/AA group, the incidence of VT/VF during hospitalization was significantly higher in the low ratio group ( p  = 0.008). Receiver operating characteristic curve analysis showed that an EPA/AA ratio
ISSN:0910-8327
1615-2573
DOI:10.1007/s00380-017-1084-2