T2 mapping cardiovascular magnetic resonance identifies the presence of myocardial inflammation in patients with dilated cardiomyopathy as compared to endomyocardial biopsy

The aim of this study was to determine the value of T2 mapping for the non-invasive assessment of myocardial inflammation in different stages of systolic left ventricular dysfunction in dilated cardiomyopathy (DCM) in comparison with endomyocardial biopsy (EMB). A total of 132 subjects were enrolled...

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Bibliographic Details
Published in:European heart journal cardiovascular imaging 2018-05, Vol.19 (5), p.574-582
Main Authors: Spieker, M, Katsianos, E, Gastl, M, Behm, P, Horn, P, Jacoby, C, Schnackenburg, B, Reinecke, P, Kelm, M, Westenfeld, R, Bönner, F
Format: Article
Language:English
Subjects:
Adult
Aged
Area Under Curve
Biopsy, Needle
Cardiomyopathy, Dilated - diagnostic imaging
Cardiomyopathy, Dilated - pathology
Case-Control Studies
Female
Follow-Up Studies
Germany
Hospitals, University
Humans
Immunohistochemistry
Magnetic Resonance Imaging, Cine - methods
Male
Middle Aged
Myocarditis - diagnostic imaging
Myocarditis - pathology
Retrospective Studies
Risk Assessment
ROC Curve
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Summary:The aim of this study was to determine the value of T2 mapping for the non-invasive assessment of myocardial inflammation in different stages of systolic left ventricular dysfunction in dilated cardiomyopathy (DCM) in comparison with endomyocardial biopsy (EMB). A total of 132 subjects were enrolled between 2013 and 2016 (62 controls and 70 patients with DCM). All patients underwent CMR at 1.5 T and received coronary angiogram and EMB. CMR applied standard protocols including T2 mapping with Gradient And SpinEcho sequence (GRASE). Global T2 relaxation time was significantly increased in patients with DCM compared to the healthy controls (T2 time DCM vs. controls: 65.9 ± 6.2 vs. 60.0 ± 4.2 ms; P 65.3 ms as the best cut-off for distinction between the healthy controls and patients with myocardial inflammation [sensitivity 93%, specificity 90%, P 
ISSN:2047-2404
2047-2412
DOI:10.1093/ehjci/jex230