Upbeat nystagmus is a useful sign in the regional diagnosis of trigeminal nerve disorder with multiple sclerosis

Trigeminal nerve disorder is an important neurological sign that is often seen with multiple sclerosis (MS). We investigated eye movements in three MS patients with trigeminal disorder due to pontine lesions near the trigeminal root entry zone (REZ). Upbeat nystagmus was observed in all MS patients...

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Bibliographic Details
Published in:Multiple sclerosis and related disorders 2018-01, Vol.19, p.59-61
Main Authors: Nakamagoe, Kiyotaka, Tozaka, Naoki, Nohara, Seitaro, Kawakami, Rio, Yamada, Shiori, Koganezawa, Tadachika, Tamaoka, Akira
Format: Article
Language:English
Subjects:
Pons
Regional diagnosis
Trigeminal neuralgia
Trigeminal paralysis
Trigeminal root entry zone
Upbeat nystagmus
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Summary:Trigeminal nerve disorder is an important neurological sign that is often seen with multiple sclerosis (MS). We investigated eye movements in three MS patients with trigeminal disorder due to pontine lesions near the trigeminal root entry zone (REZ). Upbeat nystagmus was observed in all MS patients with trigeminal REZ lesions. We conjecture that trigeminal nerve disorder and upbeat nystagmus appeared due to simultaneous damage to both the trigeminal nerve and the vestibulo-ocular reflex pathway. If upbeat nystagmus appears in MS patients exhibiting a trigeminal nerve disorder, such as trigeminal neuralgia, and paralysis, pontine lesions near the trigeminal REZ should be considered. Upbeat nystagmus can be understood as a useful sign for the clinical regional diagnosis of trigeminal nerve disorder. [Display omitted] •Upbeat nystagmus was observed in three MS patients with pontine lesions near the trigeminal REZ.•Upbeat nystagmus can be a useful sign for clinical regional diagnosis of the trigeminal REZ lesions.•The combination of nystagmus and trigeminal nerve disorders is helpful in identifying the lesions.
ISSN:2211-0348
2211-0356
DOI:10.1016/j.msard.2017.11.008