Analgesic and antidiarrheal properties of Ocimum selloi essential oil in mice

Ocimum selloi essential oil (2, 20, and 200 mg/kg; p.o.) reduced, in a dose-dependent way, the abdominal contraction induced by acetic acid (0.6%; i.p.) and the diarrhea episodes induced by castor oil in mice. At the higher dose (200 mg/kg; p.o.), the essential oil significantly reduced intestinal t...

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Bibliographic Details
Published in:Fitoterapia 2008-12, Vol.79 (7), p.569-573
Main Authors: Franca, Carolina S., Menezes, Fábia S., Costa, Larissa C.B., Niculau, Edenilson S., Alves, Péricles B., Pinto, José E.B., Marçal, Rosilene M.
Format: Article
Language:English
Subjects:
Analgesic
Antidiarrheal
Biological and medical sciences
General pharmacology
Medical sciences
Methyl chavicol
Ocimum
Ocimum selloi
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
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Summary:Ocimum selloi essential oil (2, 20, and 200 mg/kg; p.o.) reduced, in a dose-dependent way, the abdominal contraction induced by acetic acid (0.6%; i.p.) and the diarrhea episodes induced by castor oil in mice. At the higher dose (200 mg/kg; p.o.), the essential oil significantly reduced intestinal transit ( P < 0.05) in the charcoal meal test. The main component detected in O. selloi essential oil was methyl chavicol (98%; GC and GC/MS).These effects seems to support the use of O. selloi against diarrhea, intestinal spasm and visceral pain.
ISSN:0367-326X
DOI:10.1016/j.fitote.2008.06.002