Epstein-Barr Virus DNA Quantification: An Adjunctive Diagnostic Marker for AIDS-Associated Lymphoma

We report an HIV-positive patient who developed a unilateral retinitis and subsequent intracranial lesions. The finding of Epstein Barr virus (EBV) DNA at a > 1-log greater concentration in the vitreous compared to blood raised the possibility of a primary CNS non-Hodgkin's lymphoma, which w...

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Bibliographic Details
Published in:Ocular immunology and inflammation 2005-12, Vol.13 (6), p.471-473
Main Authors: Ho, Shu Fen, Fink, Colin, Murray, Philip I.
Format: Article
Language:English
Subjects:
Adult
Brain Neoplasms - complications
Brain Neoplasms - diagnosis
Brain Neoplasms - virology
Diagnosis, Differential
DNA, Viral - genetics
EBV (Epstein-Barr virus)
Epstein-Barr virus
Herpesvirus 4, Human - genetics
HIV (human immunodeficiency virus)
Human immunodeficiency virus
Humans
Lymphoma, AIDS-Related - complications
Lymphoma, AIDS-Related - diagnosis
Lymphoma, AIDS-Related - virology
Male
non-Hodgkin's lymphoma
Polymerase Chain Reaction
retinitis
Retinitis - diagnosis
Retinitis - etiology
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Summary:We report an HIV-positive patient who developed a unilateral retinitis and subsequent intracranial lesions. The finding of Epstein Barr virus (EBV) DNA at a > 1-log greater concentration in the vitreous compared to blood raised the possibility of a primary CNS non-Hodgkin's lymphoma, which was subsequently confirmed on brain biopsy. EBV DNA quantification acted as a diagnostic marker that led to a change in the management of our patient.
ISSN:0927-3948
1744-5078
DOI:10.1080/09273940590951089