The microbial metabolite indole-3-propionic acid improves glucose metabolism in rats, but does not affect behaviour

Context: We have previously shown that an antidepressant-like effect of probiotics in rats was associated with a higher plasma level of the microbial tryptophan metabolite indole-3-propionic acid (IPA). Objective: We therefore wanted to study the isolated effect of IPA on behaviour and glucose metab...

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Bibliographic Details
Published in:Archives of physiology and biochemistry 2018-08, Vol.124 (4), p.306-312
Main Authors: Abildgaard, Anders, Elfving, Betina, Hokland, Marianne, Wegener, Gregers, Lund, Sten
Format: Article
Language:English
Subjects:
Animals
Anxiety - blood
Anxiety - immunology
Anxiety - metabolism
Anxiety - prevention & control
Behavior, Animal
Blood glucose
Blood Glucose - analysis
depression
Depression - blood
Depression - immunology
Depression - metabolism
Depression - prevention & control
diabetes mellitus
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - immunology
Diabetes Mellitus, Type 2 - metabolism
Diabetes Mellitus, Type 2 - prevention & control
Dietary Supplements - adverse effects
Hyperinsulinism - blood
Hyperinsulinism - immunology
Hyperinsulinism - metabolism
Hyperinsulinism - prevention & control
Hypoglycemic Agents - adverse effects
Hypoglycemic Agents - therapeutic use
Indoles - adverse effects
Indoles - therapeutic use
insulin
Insulin - blood
Insulin Resistance
Leukocyte Count
Male
Prediabetic State - blood
Prediabetic State - immunology
Prediabetic State - metabolism
Prediabetic State - prevention & control
Propionates - adverse effects
Propionates - therapeutic use
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Rats, Sprague-Dawley
xenobiotics
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Summary:Context: We have previously shown that an antidepressant-like effect of probiotics in rats was associated with a higher plasma level of the microbial tryptophan metabolite indole-3-propionic acid (IPA). Objective: We therefore wanted to study the isolated effect of IPA on behaviour and glucose metabolism in rats. Methods: Male Sprague-Dawley rats were fed control or IPA-enriched diet for six weeks (n = 12 per group) and assessed in the elevated plus maze, open field and forced swim test. Blood glucose, metabolic hormones and the white blood cell (WBC) composition were analysed. Results: IPA (mean intake 27.3 mg/kg/day) significantly lowered fasting blood glucose level by 0.42 mM (95% CI 0.11-0.73). Similarly, fasting plasma insulin levels and the homeostatic model assessment (HOMA) index of insulin resistance were reduced, whereas plasma metabolic hormones, behaviour and WBC composition remained unaffected by IPA. Conclusions: Our findings highlight IPA as a promising candidate for treatment of metabolic disorders associated with insulin resistance.
ISSN:1381-3455
1744-4160
DOI:10.1080/13813455.2017.1398262