Electrocardiographic alterations in patients consuming synthetic cannabinoids

Introduction: The aim of this study was to investigate the electrocardiographic parameters in patients consuming synthetic cannabinoids. Methods: Thirty-five patients who were consuming synthetic cannabinoids were enrolled to the study, prospectively. The control group included 35 healthy age and se...

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Bibliographic Details
Published in:Journal of psychopharmacology (Oxford) 2018-03, Vol.32 (3), p.296-301
Main Authors: Ozturk, Hayriye M, Erdogan, Mehmet, Alsancak, Yakup, Yarlioglues, Mikail, Duran, Mustafa, Boztas, M Hamid, Murat, Sani N, Ozturk, Selcuk
Format: Article
Language:English
Subjects:
Arrhythmia
Cannabinoids
Cardiac arrhythmia
Cardiovascular diseases
EKG
Electrocardiography
Heart rate
Patients
Population studies
Psychopharmacology
Ventricle
Wave dispersion
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Summary:Introduction: The aim of this study was to investigate the electrocardiographic parameters in patients consuming synthetic cannabinoids. Methods: Thirty-five patients who were consuming synthetic cannabinoids were enrolled to the study, prospectively. The control group included 35 healthy age and sex-matched volunteers. The standard 12-lead surface electrocardiograms of the study population were recorded. P maximum (Pmax), P minimum (Pmin), P wave dispersion, interatrial duration, P wave area in D2 derivation, abnormal P terminal force in V1 derivation, heart rate, QT interval, corrected QT, QT dispersion, PR interval duration and macrovolt T-wave alternans were evaluated by two experienced cardiologists. The intra-observer and inter-observer variations for all measurements were non-significant. Results: Pmax and Pmin duration was not different between the groups (p=0.96, p=0.15, respectively). However, P wave dispersion was higher in the patient group compared to control group (34±9.4, 29.5±6.6, p=0.02, respectively). QT interval was significantly higher in the patient group than the control group (380.3±25, 365.6±22.8, p=0.01, respectively). Besides, corrected QT was higher in the patient group compared to control group (415±36.8, 392±15.5, p=0.001, respectively). QT dispersion was also higher in the patient group than the control group (39.8±10.0, 29.2±5.4, p
ISSN:0269-8811
1461-7285
DOI:10.1177/0269881117736918