Lower levels of dehydroepiandrosterone sulfate are associated with more advanced liver fibrosis in chronic hepatitis C

Summary Chronic infection with the hepatitis C virus induces liver fibrosis, but it is unknown why some patients progress to advanced fibrosis while others remain with mild disease. Recently, an inverse association between serum levels of dehydroepiandrosterone sulphate (DHEA‐S) and liver fibrosis i...

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Published in:Journal of viral hepatitis 2018-03, Vol.25 (3), p.254-261
Main Authors: Araujo Neto, J. M., Coelho, H. S. M., Chindamo, M. C., Rezende, G. F. M., Nunes Pannain, V. L., Bottino, A. M. C. F., Bruzzi Porto, L. F., Luiz, R. R., Villela‐Nogueira, C. A., Perez, R. M.
Format: Article
Language:English
Subjects:
Biopsy
Chronic infection
Dehydroepiandrosterone
Dehydroepiandrosterone sulfate
dehydroepiandrosterone sulphate
Diabetes mellitus
Fatty liver
fibrogenesis
Fibrosis
Hepatitis
Hepatitis C
Liver
Liver diseases
liver fibrosis
Regression analysis
Serum levels
Steatosis
Sulfate
S‐DHEA
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Summary:Summary Chronic infection with the hepatitis C virus induces liver fibrosis, but it is unknown why some patients progress to advanced fibrosis while others remain with mild disease. Recently, an inverse association between serum levels of dehydroepiandrosterone sulphate (DHEA‐S) and liver fibrosis in patients with nonalcoholic fatty liver disease was described, and it was postulated that dehydroepiandrosterone (DHEA) has antifibrotic effects. Our aim was to compare serum DHEA‐S levels with liver fibrosis in hepatitis C patients. We collected serum samples from hepatitis C patients at the same day they underwent a liver biopsy. S‐DHEA was compared to different stages of fibrosis. Binary logistic regression models were applied to evaluate independent variables associated to fibrosis. We included 287 patients (43.9% male). According to fibrosis stages 0, 1, 2, 3 and 4, median serum DHEA‐S levels were 103 (26‐462), 73 (5‐391), 46 (4‐425), 35 (6‐292) and 28 (2‐115) μg/dL, respectively (P 
ISSN:1352-0504
1365-2893
DOI:10.1111/jvh.12812