Effects of rosuvastatin on inducible nitric oxide synthase in rats with hyperlipidaemia and periodontitis

Background and Objective Nitric oxide is a free radical that is synthesized from l‐arginine by nitric oxide synthase (NOS). The level of inducible NOS (iNOS) in gingiva with periodontitis is higher than that in healthy gingiva. The aim of this study was to evaluate the effects of rosuvastatin admini...

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Bibliographic Details
Published in:Journal of periodontal research 2018-04, Vol.53 (2), p.258-266
Main Authors: Kırzıoğlu, F. Y., Özmen, Ö., Doğan, B., Bulut, M. T., Fentoğlu, Ö., Özdem, M.
Format: Article
Language:English
Subjects:
Alveolar bone
Alveolar Bone Loss - drug therapy
Animals
Arginine
Body Weight
Bone loss
Cell Count
Cholesterol
Cholesterol - blood
Cholesterol, Dietary
Dentistry
Disease Models, Animal
Gingiva
Gingiva - diagnostic imaging
Gingiva - drug effects
Gingiva - pathology
Gum disease
Hyperlipidemia
Hyperlipidemias - complications
inducible nitric oxide synthase
Lipoproteins, LDL - blood
Male
Molar - diagnostic imaging
Molar - pathology
Nitric oxide
Nitric Oxide - metabolism
Nitric Oxide Synthase Type II - drug effects
Nitric Oxide Synthase Type II - metabolism
Nitric-oxide synthase
Periodontal diseases
Periodontitis
Periodontitis - complications
Periodontitis - pathology
Rats
Rats, Wistar
Rodents
rosuvastatin
Rosuvastatin Calcium - administration & dosage
Rosuvastatin Calcium - pharmacology
Statistical analysis
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Summary:Background and Objective Nitric oxide is a free radical that is synthesized from l‐arginine by nitric oxide synthase (NOS). The level of inducible NOS (iNOS) in gingiva with periodontitis is higher than that in healthy gingiva. The aim of this study was to evaluate the effects of rosuvastatin administration on alveolar bone loss (ABL) and iNOS(+) cell counts in gingival tissues in rats with ligature‐induced experimental periodontitis with/without hyperlipidaemia. Material and Methods The rats were randomly divided into seven groups: Hy (cholesterol‐added diet/water administration); HyP (cholesterol‐added diet/periodontitis/water administration); HyPR (cholesterol‐added diet/periodontitis/rosuvastatin administration); P (standard diet/periodontitis/water administration); PR (standard diet/periodontitis/rosuvastatin administration); C (standard diet/water administration); and R (standard diet/rosuvastatin administration). Experimental periodontitis was induced with silk ligatures, and rosuvastatin/water was administered to rats by oral gavage for the last 2 weeks of the 8‐week study. After the rats were killed in week 8, histomorphometric and histological analyses were performed. Immunostained iNOS(+) cells were counted in the gingival samples and the Mann‐Whitney U‐test was used for statistical analysis. Results The experimental groups exhibited increases in total cholesterol and low‐density lipoprotein, except for Groups C and R. The cholesterol‐added diet induced ABL in Group Hy. Of the periodontitis groups, the lowest ABL was found in Group PR. While there was a significant difference in ABL between Groups P (0.82 ± 0.15 mm) and PR (0.70 ± 0.21 mm) receiving a standard diet (P 
ISSN:0022-3484
1600-0765
DOI:10.1111/jre.12513