The expression and binding of kainate receptors is modified in different brain regions by glutamate neurotoxicity during postnatal rat development

Kainic acid receptor (KA‐R) subunits are differentially expressed during brain development, and they modulate both neural growth and survival. High concentrations of glutamate in the brain can induce neuronal injury through these receptors, altering normal development. However, it is unclear whether...

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Bibliographic Details
Published in:International journal of developmental neuroscience 2007-02, Vol.25 (1), p.53-61
Main Authors: Beas‐Zárate, C., Ureña‐Guerrero, M.E., Flores‐Soto, M., Armendariz‐Borunda, J., Ortuño‐Sahagún, D.
Format: Article
Language:English
Subjects:
Age Factors
Animals
Animals, Newborn
Brain - anatomy & histology
Brain - drug effects
Brain - growth & development
Brain regions
Development
Expression
Gene Expression Regulation, Developmental - drug effects
Glutamate
Glutamic Acid - toxicity
Kainate receptors
Neurotoxicity
Protein Binding - drug effects
Rats
Rats, Wistar
Receptors, Kainic Acid - genetics
Receptors, Kainic Acid - metabolism
Tritium - pharmacokinetics
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Summary:Kainic acid receptor (KA‐R) subunits are differentially expressed during brain development, and they modulate both neural growth and survival. High concentrations of glutamate in the brain can induce neuronal injury through these receptors, altering normal development. However, it is unclear whether KAR subunit expression itself is also modified by neonatal exposure to high glutamate. To analyze this, monosodium glutamate (4 mg/g of body weight) was subcutaneously administered on postnatal days 1, 3, 5 and 7, and the expression of GluR5, GluR6, KA1 and KA2, as well as [3H]‐kainic acid (KA‐R) binding, was evaluated on postnatal days 14, 21, 30 and 60 in different regions of rat brain. As a result, high levels of GluR5 expression associated with strong [3H]‐kainic acid binding were observed on postnatal days 30 and 60 in the cerebral cortex of rats exposed to glutamate. Similarly, the changes induced by glutamate administration in the expression of the KA1 and KA2 subunits were paralleled by those of [3H]‐kainic acid binding in the striatum at postnatal days 21 and 30. In contrast, while KAR subunits were over expressed in the hippocampus, no changes were observed in [3H]‐kainic acid binding in adult rats that had been exposed to glutamate. Therefore, glutamate modifies both the expression of kainic acid receptor subunits and kainic acid binding in a determined spatial and temporal manner, which may be indicative of a regional susceptibility to glutamate neurotoxicity.
ISSN:0736-5748
1873-474X
DOI:10.1016/j.ijdevneu.2006.10.001