Lower trial participation by culturally and linguistically diverse (CALD) cancer patients is largely due to language barriers

Aim Clinical trials play a critical role in advancing cancer care, but international research shows that few cancer patients, particularly culturally and linguistically diverse (CALD) patients, participate in trials. This limits generalizability of trial results and increases health disparities. Thi...

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Bibliographic Details
Published in:Asia-Pacific journal of clinical oncology 2018-02, Vol.14 (1), p.52-60
Main Authors: Smith, Allan ‘Ben’, Agar, Meera, Delaney, Geoff, Descallar, Joseph, Dobell‐Brown, Kelsey, Grand, Melissa, Aung, Jennifer, Patel, Pinky, Kaadan, Nasreen, Girgis, Afaf
Format: Article
Language:English
Subjects:
Aged
Cancer
Clinical trials
Clinical Trials as Topic - methods
Clinical Trials as Topic - statistics & numerical data
Communication Barriers
Cultural Diversity
culturally and linguistically diverse
Female
Humans
Language
Male
Middle Aged
migrants
Neoplasm Staging
Neoplasms - epidemiology
Neoplasms - ethnology
Neoplasms - pathology
Neoplasms - therapy
New South Wales - epidemiology
Participation
Patient Participation - methods
Patient Participation - statistics & numerical data
Retrospective Studies
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Summary:Aim Clinical trials play a critical role in advancing cancer care, but international research shows that few cancer patients, particularly culturally and linguistically diverse (CALD) patients, participate in trials. This limits generalizability of trial results and increases health disparities. This study aimed to establish rates and correlates of trial participation among CALD patients in South Western Sydney Local Health District (SWSLHD), a highly culturally diverse area. Methods Data from all cancer patients diagnosed and/or treated in SWSLHD from January 2006 to July 2016 were analyzed retrospectively. The primary outcome was trial enrolment among patients born in non‐English speaking countries (CALD) versus English speaking countries (non‐CALD). Multivariable logistic regression evaluated CALD status as a predictor of trial participation. Moderators of trial participation by the different CALD groups, namely those whose preferred language was English (CALD‐PLE) or was not English (CALD‐PLNE), were examined by testing interactions between CALD status and other demographic and clinical variables. Results A total of 19 453 patients were analyzed (54.9% non‐CALD, 16.5% CALD‐PLE, 18.5% CALD‐PLNE). Overall, 7.4% of patients were enrolled in a trial. Trial participation was significantly lower in CALD patients than non‐CALD patients (5.7% vs 8.4%; odds ratio [OR] = 0.80; 95% confidence interval [CI], 0.69–0.91; P = 0.001). CALD‐PLNE patients were less likely to participate in trials than non‐CALD (OR = 0.45; 95% CI, 0.36–0.56; P 
ISSN:1743-7555
1743-7563
DOI:10.1111/ajco.12818