The synergy of diammonium glycyrrhizinate remarkably reduces the toxicity of oxymatrine in ICR mice

[Display omitted] Most traditional Chinese medicine prescription dosages are imprecise. This study analyzes the toxicities and adverse effects of a combination the active ingredients of licorice and Kushen medicine: oxymatrine (OMT) and diammonium glycyrrhizinate (DG). The median lethal dose (LD50)...

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Bibliographic Details
Published in:Biomedicine & pharmacotherapy 2018-01, Vol.97, p.19-25
Main Authors: Shi, Hui-Juan, Song, Hong-Bin, Wang, Le, Xiao, Sheng-Xiang, Bo, Kai-Ping, Ma, Wei
Format: Article
Language:English
Subjects:
Alanine Transaminase - antagonists & inhibitors
Alanine Transaminase - blood
Alkaloids - administration & dosage
Alkaloids - antagonists & inhibitors
Alkaloids - toxicity
Animals
Anti-Arrhythmia Agents - administration & dosage
Anti-Arrhythmia Agents - toxicity
Anti-Inflammatory Agents - administration & dosage
Aspartate Aminotransferases - antagonists & inhibitors
Aspartate Aminotransferases - blood
Body Weight - drug effects
Body Weight - physiology
Combination
Diammonium glycyrrhizinate
Female
Glycyrrhizic Acid - administration & dosage
Male
Mice
Mice, Inbred ICR
Mortality - trends
Oxymatrine
Quinolizines - administration & dosage
Quinolizines - antagonists & inhibitors
Quinolizines - toxicity
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Toxicological effect
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Summary:[Display omitted] Most traditional Chinese medicine prescription dosages are imprecise. This study analyzes the toxicities and adverse effects of a combination the active ingredients of licorice and Kushen medicine: oxymatrine (OMT) and diammonium glycyrrhizinate (DG). The median lethal dose (LD50) and mortality were analyzed in single-dose OMT (or DG) intraperitoneally injected mice with or without combination DG (or OMT). Body weight changes as well as levels of serum sodium and potassium, alanine transaminase (ALT), aspartate transaminase (AST), creatinine, and urea were measured in mice treated with a daily dose of OMT and/or DG for 14days. This study showed that the LD50 of OMT for males and females were 347.44 and 429.15mg/kg, respectively. The LD50 of DG were 525.10 and 997.26mg/kg for males and females, respectively. DG significantly decreased the mice LD50-induced mortality of the OMT, however OMT did not succeed in reducing the LD50-induced mortality rate of DG. The combination of OMT and DG obviously attenuated the changes of the body weight, serum sodium, and potassium induced by DG or OMT alone. These results suggested that toxicity and adverse effects of the OMT was significantly attenuated by DG. The OMT neutralized the adverse effects of the DG, but not the toxicity.
ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2017.09.039