Substance P and dopamine interact to modulate the distribution of delta‐opioid receptors on cholinergic interneurons in the striatum

It has been recently demonstrated that predictive learning induces a persistent accumulation of delta‐opioid receptors (DOPrs) at the somatic membrane of cholinergic interneurons (CINs) in the nucleus accumbens shell (Nac‐S). This accumulation is required for predictive learning to influence subsequ...

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Bibliographic Details
Published in:The European journal of neuroscience 2018-05, Vol.47 (10), p.1159-1173
Main Authors: Heath, Emily, Chieng, Billy, Christie, Macdonald J., Balleine, Bernard W.
Format: Article
Language:English
Subjects:
chloro‐APB
Choice learning
Cocaine
Dopamine
Dopamine D1 receptors
Dopamine D2 receptors
dorsal striatum
Interneurons
Microenvironments
Naltrindole
Narcotics
Neostriatum
NK1 receptor
Nucleus accumbens
Opioid receptors (type delta)
Quinpirole
Substance P
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Summary:It has been recently demonstrated that predictive learning induces a persistent accumulation of delta‐opioid receptors (DOPrs) at the somatic membrane of cholinergic interneurons (CINs) in the nucleus accumbens shell (Nac‐S). This accumulation is required for predictive learning to influence subsequent choice between goal‐directed actions. The current experiments investigated the local neurochemical events responsible for this translocation. We found that (1) local administration of substance P into multiple striatal sub‐territories induced DOPr translocation and (2) that this effect was mediated by the NK1 receptor, likely through its expression on CINs. Interestingly, whereas intrastriatal infusion of the D1 agonist chloro‐APB reduced the DOPr translocation on CINs and infusion of the D2 agonist quinpirole had no effect, co‐administration of both agonists again generated DOPr translocation, suggesting the effect of the D1 agonist alone was due to receptor internalisation. In support of this, local administration of cocaine was found to increase DOPr translocation as was chloro‐APB when co‐administered with the DOPr antagonist naltrindole. These studies provide the first evidence of delta‐opioid receptor translocation in striatal cholinergic interneurons outside of the accumbens shell and suggest that, despite differences in local striatal neurochemical microenvironments, a similar molecular mechanism – involving an interaction between dopamine and SP signalling via NK1R – regulates DOPr translocation in multiple striatal regions. To our knowledge, this represents a novel mechanism by which DOPr distribution is regulated that may be particularly relevant to learning‐induced DOPr trafficking. Delta‐opioid receptor translocation occurs in response to Pavlovian conditioning on striatal cholinergic interneurons in the accumbens shell. We show that this effect is mediated by an interaction between dopamine and SP signalling via NK1R. Furthermore, this translocation event occurs under similar conditions in both the ventral and dorsal striata. This finding provides evidence of a novel mechanism by which delta‐opioid receptor distribution is regulated.
ISSN:0953-816X
1460-9568
DOI:10.1111/ejn.13750