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Pharmacogenetic Analysis of Liver Toxicity after Busulfan/Cyclophosphamide-based Allogeneic Hematopoietic Stem Cell Transplantation
The aim of this study was to evaluate the impact of genomic polymorphisms of methylene-tetrahydrofolate-reductase (MTHFR-C677T, MTHFR-A1298C) and various glutathione S-transferases (GSTP1-Ile105Val, GSTA1*a/b, GSTM1, GSTT1) on the occurrence of liver toxicity in patients receiving allogeneic hematop...
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Published in: | Anticancer research 2007-11, Vol.27 (6C), p.4377-4380 |
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Main Authors: | , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
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Summary: | The aim of this study was to evaluate the impact of genomic polymorphisms of methylene-tetrahydrofolate-reductase (MTHFR-C677T,
MTHFR-A1298C) and various glutathione S-transferases (GSTP1-Ile105Val, GSTA1*a/b, GSTM1, GSTT1) on the occurrence of liver
toxicity in patients receiving allogeneic hematopoietic stem cell transplantation (HSCT). Patients and Methods: Eighty-four
adult patients were enrolled in this retrospective study. All patients were treated with busulfan/cyclophosphamide as a conditioning
regimen and received cyclosporine and short-course MTX for GvHD prophylaxis. Genotyping was performed using PCR based restriction-fragment-length-polymorphism
(RFLP) techniques. Results: Multivariate analysis identified the MTHFR-A1298C polymorphism as an independent predictor for
maximum levels of bilirubin (p=0.0025) and duration of hyperbilirubinaemia (p=0.013). Furthermore, there was an association
between this polymorphism and the occurrence of the sinusoidal obstruction syndrome (SOS) (p=0.048). No significant associations
between the MTHFR-C677T or the various GST polymorphisms and liver toxicity were observed. Conclusion: The MTHFR-A1298C polymorphism
might be associated with liver toxicity in patients receiving allogeneic HSCT. |
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ISSN: | 0250-7005 1791-7530 |