Late Effects of Radiation on the Central Nervous System: Role of Vascular Endothelial Damage and Glial Stem Cell Survival

Coderre, J. A., Morris, G. M., Micca, P. L., Hopewell, J. W., Verhagen, I., Kleiboer, B. J. and van der Kogel, A. J. Late Effects of Radiation on the Central Nervous System: Role of Vascular Endothelial Damage and Glial Stem Cell Survival. Radiat. Res. 166, 495–503 (2006). Selective irradiation of t...

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Published in:Radiation research 2006-09, Vol.166 (3), p.495-503
Main Authors: Coderre, Jeffrey A., Morris, Gerard M., Micca, Peggy L., Hopewell, John W., Verhagen, Ilja, Kleiboer, Bert J., van der Kogel, Albert J.
Format: Article
Language:English
Subjects:
Animals
Blood
Boron
Cell Survival - radiation effects
Cells, Cultured
Dose-Response Relationship, Radiation
Dosimetry
Endothelial cells
Endothelium, Vascular - injuries
Endothelium, Vascular - pathology
Endothelium, Vascular - radiation effects
Irradiation
Male
Neuroglia - pathology
Neuroglia - radiation effects
Progenitor cells
Radiation Dosage
Radiation Injuries - etiology
Radiation Injuries - pathology
Rats
Rats, Inbred F344
Spinal cord
Spinal Cord - blood supply
Spinal Cord - radiation effects
Spinal cord diseases
Spinal Cord Diseases - etiology
Spinal Cord Diseases - pathology
Thermal neutrons
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Summary:Coderre, J. A., Morris, G. M., Micca, P. L., Hopewell, J. W., Verhagen, I., Kleiboer, B. J. and van der Kogel, A. J. Late Effects of Radiation on the Central Nervous System: Role of Vascular Endothelial Damage and Glial Stem Cell Survival. Radiat. Res. 166, 495–503 (2006). Selective irradiation of the vasculature of the rat spinal cord was used in this study, which was designed specifically to address the question as to whether it is the endothelial cell or the glial progenitor cell that is the target responsible for late white matter necrosis in the CNS. Selective irradiation of the vascular endothelium was achieved by the intraperitoneal (ip) administration of a boron compound known as BSH (Na2B12H11SH), followed by local irradiation with thermal neutrons. The blood-brain barrier is known to exclude BSH from the CNS parenchyma. Thirty minutes after the ip injection of BSH, the boron concentration in blood was 100 μg 10B/ g, while that in the CNS parenchyma was below the detection limit of the boron analysis system,
ISSN:0033-7587
1938-5404
DOI:10.1667/RR3597.1