Integrons in Enterobacteriaceae: diversity, distribution and epidemiology

•Review of the distribution, diversity and global trends of integrons in important members of the Enterobacteriaceae.•Role of integrons in the spread, evolution and dissemination of multidrug resistance in Enterobacteriaceae.•Clinical relevance of integron-associated antibiotic resistance.•Changing...

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Bibliographic Details
Published in:International journal of antimicrobial agents 2018-02, Vol.51 (2), p.167-176
Main Authors: Kaushik, Megha, Kumar, Sanjay, Kapoor, Rajeev Kumar, Virdi, Jugsharan Singh, Gulati, Pooja
Format: Article
Language:English
Subjects:
Drug Resistance, Multiple, Bacterial - genetics
Enterobacteriaceae
Enterobacteriaceae - drug effects
Enterobacteriaceae - genetics
Enterobacteriaceae - isolation & purification
Enterobacteriaceae Infections - drug therapy
Enterobacteriaceae Infections - epidemiology
Enterobacteriaceae Infections - microbiology
Epidemiology
Gastrointestinal Microbiome - genetics
Gene cassettes
Humans
Integrons
Integrons - genetics
Multiple antibiotic resistance
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Summary:•Review of the distribution, diversity and global trends of integrons in important members of the Enterobacteriaceae.•Role of integrons in the spread, evolution and dissemination of multidrug resistance in Enterobacteriaceae.•Clinical relevance of integron-associated antibiotic resistance.•Changing patterns and complexity of integron gene content and growing frequency of integrons in enteric bacteria. Integrons are versatile gene acquisition systems that allow efficient capturing of exogenous genes and ensure their expression. Various classes of integrons possessing a wide variety of gene cassettes are ubiquitously distributed in enteric bacteria worldwide. The epidemiology of integrons associated multidrug resistance in Enterobacteriaceae is rapidly evolving. In the past two decades, the incidence of integrons in enteric bacteria has increased drastically with evolution of multiple gene cassettes, novel gene arrangements and complex chromosomal integrons such as Salmonella genomic islands. This review focuses on the distribution, versatility, spread and global trends of integrons among important members of the Enterobacteriaceae, including Escherichia coli, Klebsiella, Shigella and Salmonella, which are known to cause infections globally. Such a comprehensive understanding of integron-associated antibiotic resistance, their role in the spread of such resistance traits and their clinical relevance especially with regard to each genus individually is paramount to contain the global spread of antibiotic resistance.
ISSN:0924-8579
1872-7913
DOI:10.1016/j.ijantimicag.2017.10.004