Effect of human milk formula with bovine colostrum supplementation on bone mineral density in infant cynomolgus macaques

Insulin-like growth factor 1 (IGF1) is a regulator of human growth during infancy and childhood, known to promote bone and muscle growth as well as lipid accumulation. This study aimed to investigate the effects of formula milk with or without IGF1 supplementation (in the form of pure IGF1 or bovine...

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Bibliographic Details
Published in:Journal of developmental origins of health and disease 2018-04, Vol.9 (2), p.172-181
Main Authors: Tay, N, Tan, Y C, Chng, K, Libedinsky, C, Gluckman, P, Buschdorf, J P
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Baby foods
Body Composition - drug effects
Body Composition - physiology
Bone Density - drug effects
Bone Density - physiology
Cattle
Colostrum - physiology
Female
Humans
Insulin-Like Growth Factor I - administration & dosage
Insulin-like growth factors
Macaca fascicularis
Male
Milk, Human - physiology
Nutrition
Obesity
Physical growth
Pregnancy
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Summary:Insulin-like growth factor 1 (IGF1) is a regulator of human growth during infancy and childhood, known to promote bone and muscle growth as well as lipid accumulation. This study aimed to investigate the effects of formula milk with or without IGF1 supplementation (in the form of pure IGF1 or bovine colostrum) on growth and body composition in infant cynomolgus macaques during the first 6 months of life. Three groups of infants were nursery-reared and received formula milk with or without IGF1 or bovine colostrum supplementation for 4 months, and a fourth group consisting of breast-fed infants was included for comparison (n=6 for each group). Ranked-based analysis of covariance was used to detect differences between adjusted means for sex. No differences in weight, height, fat mass, and fat-free mass could be detected between groups. However, bone mineral density (BMD) was significantly different between groups at the end of formula feeding. Infants that received bovine colostrum supplementation displayed higher mean BMD than infants of all other groups, with no differences between the latter three groups. In conclusion, our results suggest that supplementation with bovine colostrum can enhance BMD in formula-fed infants, an effect that apparently does not depend on IGF1. Bovine colostrum supplementation could be beneficial for long-term bone health in infants with suboptimal bone growth.
ISSN:2040-1744
2040-1752
DOI:10.1017/S2040174417000812