Recent Exposure to Particulate Matter and C-reactive Protein Concentration in the Multi-Ethnic Study of Atherosclerosis

Ambient levels of particulate matter have been linked to cardiovascular disease. The mechanisms mediating these associations are poorly understood. One candidate mechanism is inflammation. Using data from the Multi-Ethnic Study of Atherosclerosis (2000–2002), the authors investigated the relation be...

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Bibliographic Details
Published in:	American journal of epidemiology 2006-09, Vol.164 (5), p.437-448
Main Authors:	Diez Roux, A. V., Auchincloss, A. H., Astor, B., Barr, R. G., Cushman, M., Dvonch, T., Jacobs, D. R., Kaufman, J., Lin, X., Samson, P.
Format:	Article
Language:	eng
Subjects:	Aged Aged, 80 and over air pollutants Air Pollutants - toxicity Air pollution Analysis. Health state Atherosclerosis (general aspects, experimental research) Atherosclerosis - chemically induced Atherosclerosis - ethnology Biological and medical sciences Blood and lymphatic vessels C-Reactive Protein - analysis Cardiology. Vascular system Cardiovascular disease cardiovascular diseases confidence interval Continental Population Groups Dust Environment. Living conditions environmental Environmental Exposure - adverse effects Environmental health Epidemiology Female General aspects Humans inflammation Inflammatory diseases Male Medical sciences MESA Middle Aged Multi-Ethnic Study of Atherosclerosis particulate matter of less than or equal to 10 μm in diameter particulate matter of less than or equal to 2.5 μm in diameter PM10 PM2.5 Proteins Public health. Hygiene Public health. Hygiene-occupational medicine Risk Factors Time Factors United States United States Environmental Protection Agency
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Summary:	Ambient levels of particulate matter have been linked to cardiovascular disease. The mechanisms mediating these associations are poorly understood. One candidate mechanism is inflammation. Using data from the Multi-Ethnic Study of Atherosclerosis (2000–2002), the authors investigated the relation between exposure to particulate matter of less than or equal to 2.5 μm in diameter (PM2.5) and C-reactive protein concentration in 5,634 persons aged 45–84 years who were free of cardiovascular disease. Data from US Environmental Protection Agency monitors were used to estimate PM2.5 exposures for the prior day, prior 2 days, prior week, prior 30 days, and prior 60 days. Only the 30-day and 60-day mean exposures showed a weak positive association with C-reactive protein, and confidence intervals were wide: relative increases in C-reactive protein per 10 μg/m3 of PM2.5 adjusted for person-level covariates were 3% (95% confidence interval (CI): –2, 10) for a 30-day mean and 4% (95% CI: –3, 11.0) for a 60-day mean. The means of 7-day, 30-day, and 60-day exposures were weakly, positively, and nonsignificantly associated with the odds of C-reactive protein of greater than or equal to 3 mg/liter: adjusted odds ratios were 1.05 (95% CI: 0.96, 1.15), 1.12 (95% CI: 0.98, 1.29), and 1.12 (95% CI: 0.96, 1.32), respectively. Slightly stronger associations were observed in persons without other risk factors for elevated C-reactive protein, but this heterogeneity was not statistically significant. The authors' results are not compatible with strong effects of particulate matter exposures on population levels of C-reactive protein.
ISSN:	0002-9262 1476-6256