Chromosomal Aberrations and Cancer Risk: Results of a Cohort Study from Central Europe

A high level of chromosomal aberrations in peripheral blood lymphocytes may be an early marker of cancer risk, but data on risk of specific cancers and types of chromosomal aberrations (chromosome type and chromatid type) are limited. A total of 6,430 healthy individuals from nine laboratories in Cr...

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Bibliographic Details
Published in:American journal of epidemiology 2007-01, Vol.165 (1), p.36-43
Main Authors: Boffetta, Paolo, van der Hel, Olga, Norppa, Hannu, Fabianova, Eleonora, Fucic, Aleksandra, Gundy, Sarolta, Lazutka, Juozas, Cebulska-Wasilewska, Antonina, Puskailerova, Daniela, Znaor, Ariana, Kelecsenyi, Zsolt, Kurtinaitis, Juozas, Rachtan, Jadwiga, Forni, Alessandra, Vermeulen, Roel, Bonassi, Stefano
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor - blood
Cancer
chromosome aberrations
Chromosome Aberrations - statistics & numerical data
Chromosome Disorders - epidemiology
Chromosome Disorders - genetics
Chromosomes
cohort studies
Cytogenetics
Epidemiology
Europe
Europe, Eastern - epidemiology
Female
Health Surveys
Humans
Kaplan-Meier Estimate
Lymphocytes
Male
Middle Aged
Mortality
Mutation
neoplasms
Neoplasms - epidemiology
Neoplasms - genetics
Neoplasms - mortality
Occupational Exposure - adverse effects
risk
Risk Assessment
Risk Factors
Smoking - adverse effects
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Summary:A high level of chromosomal aberrations in peripheral blood lymphocytes may be an early marker of cancer risk, but data on risk of specific cancers and types of chromosomal aberrations (chromosome type and chromatid type) are limited. A total of 6,430 healthy individuals from nine laboratories in Croatia, Hungary, Lithuania, Poland, and Slovakia, included in chromosomal aberration surveys performed during 1978–2002, were followed up for cancer incidence or mortality for an average of 8.5 years; 200 cancer cases were observed. Compared with that for the low-tertile level of chromosomal aberrations, the relative risks of cancer for the medium and high tertiles were 1.78 (95% confidence interval: 1.19, 2.67) and 1.81 (95% confidence interval: 1.20, 2.73), respectively. The relative risk for chromosome-type aberrations above versus below the median was 1.50 (95% confidence interval: 1.12, 2.01), while that for chromatid-type aberrations was 0.97 (95% confidence interval: 0.72, 1.31). The analyses of risk of specific cancers were limited by small numbers, but the association was stronger for stomach cancer. This study confirms the previously reported association between level of chromosomal aberrations and cancer risk and provides novel information on the type of aberrations more strongly predictive of cancer risk and on the types of cancer more strongly predicted by chromosomal aberrations.
ISSN:0002-9262
1476-6256
DOI:10.1093/aje/kwj367