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Cytotoxic effects of C-glycosides in HOS and HeLa cell lines
Fifty-two C-glycosides were synthesized and their in-vitro antiproliferative activity against human cervical carcinoma (HeLa) and osteosarcoma (HOS) screened, showing significant activity. Fifty-two C-glycosides were synthesized and their in-vitro antiproliferative activity screened against human ce...
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Published in: | Bioorganic & medicinal chemistry letters 2007-07, Vol.17 (13), p.3676-3681 |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Fifty-two
C-glycosides were synthesized and their in-vitro antiproliferative activity against human cervical carcinoma (HeLa) and osteosarcoma (HOS) screened, showing significant activity.
Fifty-two
C-glycosides were synthesized and their in-vitro antiproliferative activity screened against human cervical carcinoma (HeLa) and osteosarcoma (HOS) cell lines. Nine of them had growth inhibitions (GI
50 values) below 10
μM, the
C-glucopyranoside
38 being the most active against HeLa (5.4
μM) and the dichlorocyclopropyl derivative
42 against HOS (1.6
μM). Some preliminary structure–activity relationships were established. |
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ISSN: | 0960-894X 1464-3405 |
DOI: | 10.1016/j.bmcl.2007.04.060 |