Intraspecies variation in the efficacy of adjunctive recombinant interferon-γ therapy against cryptococcal meningoencephalitis in mice

The efficacy of recombinant interferon γ (rIFN-γ) for cryptococcal meningoencephalitis has been poorly understood. Compared to Cryptococcus gattii, rIFN-γ significantly improved the survival in experimental meningoencephalitis due to Cryptococcus neoformans. The number of phagocytic macrophages and...

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Bibliographic Details
Published in:Medical mycology (Oxford) 2018-04, Vol.56 (3), p.382-386
Main Authors: Ikeda-Dantsuji, Yurika, Nakamura, Shigeki, Ohno, Hideaki, Inukai, Tatsuya, Nagi, Minoru, Ueno, Keigo, Umeyama, Takashi, Kinjo, Yuki, Yamagoe, Satoshi, Shibuya, Kazutoshi, Miyazaki, Yoshitsugu
Format: Article
Language:English
Subjects:
Animals
Antifungal Agents - pharmacology
Antifungal Agents - therapeutic use
Cell Line
Colony Count, Microbial
Cryptococcus gattii - drug effects
Cryptococcus gattii - pathogenicity
Cryptococcus neoformans - drug effects
Cryptococcus neoformans - pathogenicity
Disease Models, Animal
Female
Interferon-gamma - pharmacology
Interferon-gamma - therapeutic use
Macrophages - cytology
Macrophages - drug effects
Macrophages - metabolism
Meningoencephalitis - drug therapy
Meningoencephalitis - microbiology
Meningoencephalitis - mortality
Meningoencephalitis - pathology
Mice
Mice, Inbred C57BL
Phagocytosis - drug effects
Species Specificity
Survival Rate
Virulence
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Summary:The efficacy of recombinant interferon γ (rIFN-γ) for cryptococcal meningoencephalitis has been poorly understood. Compared to Cryptococcus gattii, rIFN-γ significantly improved the survival in experimental meningoencephalitis due to Cryptococcus neoformans. The number of phagocytic macrophages and the levels of inflammatory cytokines production for ex vivo co-incubation with C. neoformans were increased after rIFN-γ stimulation but not C. gattii. Intraspecies differences of phagocytosis by the rIFN-γ-activated macrophages might be associated to the severity of cryptococcal infection.
ISSN:1369-3786
1460-2709
DOI:10.1093/mmy/myx063