White matter and schizophrenia: A meta-analysis of voxel-based morphometry and diffusion tensor imaging studies

Voxel-based morphometry (VBM) and diffusion tensor imaging (DTI) are the most implemented methodologies to detect alterations of both gray and white matter (WM). However, the role of WM in mental disorders is still not well defined. We aimed at clarifying the role of WM disruption in schizophrenia a...

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Bibliographic Details
Published in:Psychiatry research. Neuroimaging 2017-12, Vol.270, p.8-21
Main Authors: Vitolo, Enrico, Tatu, Mona Karina, Pignolo, Claudia, Cauda, Franco, Costa, Tommaso, Ando’, Agata, Zennaro, Alessandro
Format: Article
Language:English
Subjects:
Adult
Diffusion Tensor Imaging
Female
Humans
Likelihood Functions
Male
Meta-analysis
Middle Aged
Schizophrenia
Schizophrenia - diagnostic imaging
Schizophrenia - pathology
Schizophrenia - physiopathology
Voxel-based morphometry
White matter
White Matter - diagnostic imaging
White Matter - pathology
Young Adult
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Summary:Voxel-based morphometry (VBM) and diffusion tensor imaging (DTI) are the most implemented methodologies to detect alterations of both gray and white matter (WM). However, the role of WM in mental disorders is still not well defined. We aimed at clarifying the role of WM disruption in schizophrenia and at identifying the most frequently involved brain networks. A systematic literature search was conducted to identify VBM and DTI studies focusing on WM alterations in patients with schizophrenia compared to control subjects. We selected studies reporting the coordinates of WM reductions and we performed the anatomical likelihood estimation (ALE). Moreover, we labeled the WM bundles with an anatomical atlas and compared VBM and DTI ALE-scores of each significant WM tract. A total of 59 studies were eligible for the meta-analysis. WM alterations were reported in 31 and 34 foci with VBM and DTI methods, respectively. The most occurred WM bundles in both VBM and DTI studies and largely involved in schizophrenia were long projection fibers, callosal and commissural fibers, part of motor descending fibers, and fronto-temporal-limbic pathways. The meta-analysis showed a widespread WM disruption in schizophrenia involving specific cerebral circuits instead of well-defined regions. •White matter reductions in schizophrenia involve specific cerebral circuits.•Voxel-based morphometry (VBM) and diffusion tensor imaging (DTI) detect some shared WM bundles.•Meta-regression analyses found significant effects of age, duration of illness, and gender on several WM bundles.•The bundles detected by both methodologies may be the “core tracts” of the WM impairments in schizophrenia.•Schizophrenia seems to be characterized by several dysfunctionalities and disconnections of a widespread cerebral network.
ISSN:0925-4927
1872-7506
DOI:10.1016/j.pscychresns.2017.09.014