Circulating interleukin-15 and RANTES chemokine in Parkinson's disease

Interleukin‐15 promotes T‐cell proliferation, induction of cytolytic effector cells including natural killer (NK) and cytotoxic cells and stimulates B‐cell to proliferate and secrete immunoglobulins. RANTES is a C‐C beta chemokine with strong chemoattractant activity for T lymphocytes and monocytes....

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Bibliographic Details
Published in:Acta neurologica Scandinavica 2007-12, Vol.116 (6), p.374-379
Main Authors: Rentzos, M., Nikolaou, C., Andreadou, E., Paraskevas, G. P., Rombos, A., Zoga, M., Tsoutsou, A., Boufidou, F., Kapaki, E., Vassilopoulos, D.
Format: Article
Language:English
Subjects:
Age Factors
Aged
Antiparkinson Agents - adverse effects
Biological and medical sciences
Biomarkers - analysis
Biomarkers - blood
Chemokine CCL5 - blood
Chemokine CCL5 - immunology
Chemotaxis, Leukocyte - immunology
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes
Elisa
Encephalitis - blood
Encephalitis - immunology
Encephalitis - physiopathology
Female
Humans
IL-15
Immunoassay
immunological disturbances
Interleukin-15 - blood
Interleukin-15 - immunology
L-dopa treatment
Lymphocyte Activation - immunology
Male
Medical sciences
Middle Aged
Nervous system (semeiology, syndromes)
Neurology
Parkinson Disease - blood
Parkinson Disease - immunology
Parkinson Disease - physiopathology
Parkinson's disease
RANTES
serum
Sex Factors
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Summary:Interleukin‐15 promotes T‐cell proliferation, induction of cytolytic effector cells including natural killer (NK) and cytotoxic cells and stimulates B‐cell to proliferate and secrete immunoglobulins. RANTES is a C‐C beta chemokine with strong chemoattractant activity for T lymphocytes and monocytes. Objectives –  The objective of our study was to find out whether IL‐15 and RANTES are involved in the possible inflammatory reactions of PD. Patients and methods –  We measured by immunoassay serum IL‐15 and RANTES levels in 41 patients with PD in comparison with serum levels in 19 healthy subjects age and sex‐matched. IL‐15 and RANTES levels were correlated with sex, age, disease duration. H‐Y stage and the UPDRS III score in all the studied groups and were also correlated with treatment status in PD patients. Results –  The PD group presented with significantly increased RANTES levels as compared to the control group (P = 0.0009). No difference was observed as regards IL‐15 levels. A strong and significant correlation between RANTES levels and UPDRS III score was observed in PD patients (Rs = 0.42, P = 0.007). Untreated patients had significantly higher RANTES levels as compared to the controls. Conclusions –  Our findings may suggest a recruitment of activated monocytes, macrophages and T lymphocytes to sites of inflammation in the central nervous system of PD patients.
ISSN:0001-6314
1600-0404
DOI:10.1111/j.1600-0404.2007.00894.x