Nitric oxide-activatable gold nanoparticles for specific targeting and photo-thermal ablation of macrophages

In this study, we designed NO-activatable gold nanoparticles (NAM-AuNPs) for specific targeting and photo-thermal ablation of macrophages. The gold nanoparticles showed aggregation behavior in response to NO solution as well as endogenous NO secreted from activated macrophages. Following NIR irradia...

Full description

Saved in:
Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2017-10, Vol.53 (81), p.11229-11232
Main Authors: Park, Junghong, Pramanick, Swapan, Kim, Jinhwan, Lee, Jihyun, Kim, Won Jong
Format: Article
Language:English
Subjects:
Animals
Cell Survival - drug effects
Dose-Response Relationship, Drug
Gold - chemistry
Gold - pharmacology
Lipopolysaccharides - pharmacology
Macrophages - drug effects
Metal Nanoparticles - chemistry
Mice
Molecular Structure
NIH 3T3 Cells
Nitric Oxide - biosynthesis
Nitric Oxide - chemistry
Nitric Oxide - pharmacology
Particle Size
Phototherapy
RAW 264.7 Cells
Structure-Activity Relationship
Temperature
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this study, we designed NO-activatable gold nanoparticles (NAM-AuNPs) for specific targeting and photo-thermal ablation of macrophages. The gold nanoparticles showed aggregation behavior in response to NO solution as well as endogenous NO secreted from activated macrophages. Following NIR irradiation, significant cytotoxicity was observed in activated RAW 264.7 cells treated with NAM-AuNPs.
ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc06420a