Biodegradation or metabolism of bisphenol A: From microorganisms to mammals

Bisphenol A (BPA; 2,2-bis(4-hydroxyphenyl)propane; CAS Registry No. 80-05-7) is one of endocrine disruptors and is made by combining acetone and phenol. BPA can be metabolized by extensive organisms. In this review these BPA biodegradations or metabolisms by many organisms from microorganisms to mam...

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Bibliographic Details
Published in:Toxicology (Amsterdam) 2006-01, Vol.217 (2), p.81-90
Main Authors: Kang, Jeong-Hun, Katayama, Yoshiki, Kondo, Fusao
Format: Article
Language:English
Subjects:
Animals
Bacteria - metabolism
Benzhydryl Compounds
Biodegradation
Biodegradation, Environmental
Biological and medical sciences
Bisphenol A
Estrogenic activity
Fungi - metabolism
Humans
Mammals - metabolism
Medical sciences
Metabolism
Phenols - metabolism
Plankton - metabolism
Toxic activity
Toxicology
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Summary:Bisphenol A (BPA; 2,2-bis(4-hydroxyphenyl)propane; CAS Registry No. 80-05-7) is one of endocrine disruptors and is made by combining acetone and phenol. BPA can be metabolized by extensive organisms. In this review these BPA biodegradations or metabolisms by many organisms from microorganisms to mammals were referred. Though the metabolites of BPA can enhance estrogenicity or toxicity, generally, BPA metabolism by organisms leads to detoxication of BPA.
ISSN:0300-483X
1879-3185
DOI:10.1016/j.tox.2005.10.001