Loading…
ORIGINAL ARTICLE: Neutrophil Function During Pregnancy: Is Nitric Oxide Production Correlated with Superoxide Production?
Problem: Oxygen radical formation by neutrophils during pregnancy is not well studied. Method of study: We studied neutrophil-derived superoxide anion (O[unconverted image]) and nitric oxide (NO) values in 75 normal pregnant women, 12 postpartum women, and 10 non-pregnant women. O[unconverted image]...
Saved in:
Published in: | American Journal of Reproductive Immunology and Microbiology 2006-02, Vol.55 (2), p.99-105 |
---|---|
Main Authors: | , , , |
Format: | Article |
Language: | English |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | Problem: Oxygen radical formation by neutrophils during pregnancy is not well studied. Method of study: We studied neutrophil-derived superoxide anion (O[unconverted image]) and nitric oxide (NO) values in 75 normal pregnant women, 12 postpartum women, and 10 non-pregnant women. O[unconverted image] production was measured by the superoxide dismutase-inhibitable reduction of ferricytochrome c. NO production was measured by accumulation of the stable end product nitrite using a modified Griess reaction method. Results: O[unconverted image] production of neutrophils stimulated by chemotactic peptide was significantly enhanced in the early second trimester of pregnancy. l-arginine analogue-inhibitable nitrite production was induced in neutrophils from pregnant women, but not from postpartum and non-pregnant subjects. In third-trimester subjects but not non-pregnant subjects, neutrophils pre-treated with l-arginine analogues enhanced O[unconverted image] production compared with untreated neutrophils. Conclusion: These findings indicate that O[unconverted image] and NO production by neutrophils during pregnancy were modulated separately, whereas neutrophil-derived NO might function as a regulator of O[unconverted image]. |
---|---|
ISSN: | 8755-8920 1365-2567 |
DOI: | 10.1111/j.1600-0897.2005.00324.x |