Foreseeing the future of glomerular disease through slits: miR-NPNT axis

Podocyte biology is an important key factor for the maintenance of glomerular function and structure. Nephronectin is a podocyte-derived extracellular matrix protein in the glomerular basement membrane. Suppression of nephronectin expression by microRNA-378a-3p significantly induced proteinuria due...

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Bibliographic Details
Published in:Kidney international 2017-10, Vol.92 (4), p.782-784
Main Authors: Inagi, Reiko, Ishimoto, Yu, Jao, Tzu-Ming
Format: Article
Language:English
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Summary:Podocyte biology is an important key factor for the maintenance of glomerular function and structure. Nephronectin is a podocyte-derived extracellular matrix protein in the glomerular basement membrane. Suppression of nephronectin expression by microRNA-378a-3p significantly induced proteinuria due to loss of integrity of the glomerular filtration barrier in zebrafish and mice, demonstrating the relevance of the microRNA-nephronectin axis in regulation of the podocyte–glomerular basement membrane interaction and integrity of the glomerular filtration barrier.
ISSN:0085-2538
1523-1755
DOI:10.1016/j.kint.2017.04.036