Higher Prevalence and Faster Progression of Chronic Kidney Disease in Human Immunodeficiency Virus–Infected Middle-Aged Individuals Compared With Human Immunodeficiency Virus–Uninfected Controls

Summary In this cohort of human immunodeficiency virus (HIV)–infected and HIV-uninfected individuals aged ≥45 years, HIV infection was independently associated with renal impairment, albuminuria, and proximal renal tubular dysfunction. Compared with HIV-uninfected individuals, HIV-infected individua...

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Published in:The Journal of infectious diseases 2017-09, Vol.216 (6), p.622-631
Main Authors: Kooij, Katherine W., Vogt, Liffert, Wit, Ferdinand W. N. M., van der Valk, Marc, van Zoest, Rosan A., Goorhuis, Abraham, Prins, Maria, Post, Frank A., Reiss, Peter
Format: Article
Language:English
Subjects:
Albuminuria - complications
Albuminuria - drug therapy
Anti-HIV Agents - therapeutic use
Case-Control Studies
Disease Progression
Female
Follow-Up Studies
Glomerular Filtration Rate
HIV Infections - complications
HIV Infections - drug therapy
HIV/AIDS
Humans
Logistic Models
Longitudinal Studies
Male
Middle Aged
Multivariate Analysis
Phosphates - blood
Prevalence
Prospective Studies
Renal Insufficiency, Chronic - complications
Renal Insufficiency, Chronic - drug therapy
Risk Factors
Tenofovir - therapeutic use
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Summary:Summary In this cohort of human immunodeficiency virus (HIV)–infected and HIV-uninfected individuals aged ≥45 years, HIV infection was independently associated with renal impairment, albuminuria, and proximal renal tubular dysfunction. Compared with HIV-uninfected individuals, HIV-infected individuals on combination antiretroviral therapy were more likely to experience estimated glomerular filtration rate decline and worsening albuminuria during 4 years of follow-up. Abstract Background Human immunodeficiency virus (HIV)–infected individuals are at increased risk of chronic kidney disease (CKD). Human immunodeficiency virus infection, traditional CKD risk factors, and combination antiretroviral therapy (cART) may all contribute. Methods We compared prevalence of renal impairment (estimated glomerular filtration rate [eGFR] 2.93μg/mmol and/or fractional phosphate excretion >20% with plasma phosphate
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jix202