Nutrition, Intestinal Permeability, and Blood Ethanol Levels Are Altered in Patients with Nonalcoholic Fatty Liver Disease (NAFLD)

Background A role of an altered dietary pattern (e.g., a diet rich in sugar) but also alterations at the level of the intestinal barrier have repeatedly been discussed to be involved in the development and progression of nonalcoholic fatty liver disease (NAFLD). Aims To determine if the nutritional...

Full description

Saved in:
Bibliographic Details
Published in:Digestive diseases and sciences 2012-07, Vol.57 (7), p.1932-1941
Main Authors: Volynets, Valentina, Küper, Markus A., Strahl, Stefan, Maier, Ina B., Spruss, Astrid, Wagnerberger, Sabine, Königsrainer, Alfred, Bischoff, Stephan C., Bergheim, Ina
Format: Article
Language:English
Subjects:
Acetaldehyde
Adult
Alcohol
Alcohol, Denatured
Biochemistry
Case-Control Studies
Development and progression
Dietary Carbohydrates - pharmacology
Dietary Proteins - pharmacology
Disease Progression
Endotoxins - blood
Ethanol - blood
Fatty liver
Fatty Liver - blood
Fatty Liver - physiopathology
Female
Food habits
Gastroenterology
Hepatology
Humans
Intestines - microbiology
Intestines - physiology
Male
Medicine
Medicine & Public Health
Microbiota (Symbiotic organisms)
Non-alcoholic Fatty Liver Disease
Nutritional Status - physiology
Oncology
Original Article
Permeability
Permeability - drug effects
Plasminogen Activator Inhibitor 1 - blood
Sugars
Transplant Surgery
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background A role of an altered dietary pattern (e.g., a diet rich in sugar) but also alterations at the level of the intestinal barrier have repeatedly been discussed to be involved in the development and progression of nonalcoholic fatty liver disease (NAFLD). Aims To determine if the nutritional intake, intestinal flora, and permeability and the development of NAFLD are related in humans. Methods Ten controls and 20 patients with NAFLD ranging from simple steatosis to steatohepatitis were included in the study. Bacterial overgrowth, orocecal transit time, and intestinal permeability were assessed. Alcohol, endotoxin, and plasminogen activator inhibitor (PAI-) 1 concentration were determined in plasma. Nutritional intake was assessed using a dietary history. Results Despite no differences in the prevalence of bacterial overgrowth and in the orocecal transit time, intestinal permeability, alcohol, and endotoxin levels in plasma were significantly higher in patients with NAFLD than in controls. Similar results were also found for PAI-1 plasma concentrations. Patients with NAFLD had a significantly higher intake of protein, total carbohydrates, and mono- as well as disaccharides than controls. PAI-1, endotoxin, and ALT plasma levels were positively related to total protein and carbohydrate intake. Conclusions Taken together, our results indicate that intestinal permeability, endogenous alcohol synthesis, and nutritional intake are markedly altered in patients with NAFLD.
ISSN:0163-2116
1573-2568
DOI:10.1007/s10620-012-2112-9