The Use of a 3895 bp Mitochondrial DNA Deletion as a Marker for Sunlight Exposure in Human Skin

Previous work has examined the use of mitochondrial DNA (mtDNA) damage as a biomarker of cumulative sun exposure in human skin. These studies have simply compared mtDNA damage between sun-protected and sun exposed skin. This approach is limited because non-melanoma skin cancer (NMSC) is predominantl...

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Bibliographic Details
Published in:Journal of investigative dermatology 2004-12, Vol.123 (6), p.1020-1024
Main Authors: Krishnan, Kim J., Harbottle, Andrew, Birch-Machin, Mark A.
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
biomarker
Cell Line, Transformed
Chromosome aberrations
Dermatology
DNA deletion
DNA, Mitochondrial - blood
DNA, Mitochondrial - genetics
DNA, Mitochondrial - radiation effects
Dose-Response Relationship, Radiation
Epidermis - physiopathology
Epidermis - radiation effects
Gene Deletion
Genetic Markers
Humans
Keratinocytes - cytology
Keratinocytes - physiology
Keratinocytes - radiation effects
Medical genetics
Medical sciences
Middle Aged
mitochondrial DNA
skin cancer
Sunlight - adverse effects
Tumors of the skin and soft tissue. Premalignant lesions
ultraviolet radiation
Ultraviolet Rays - adverse effects
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Summary:Previous work has examined the use of mitochondrial DNA (mtDNA) damage as a biomarker of cumulative sun exposure in human skin. These studies have simply compared mtDNA damage between sun-protected and sun exposed skin. This approach is limited because non-melanoma skin cancer (NMSC) is predominantly formed on body sites which are ‘usually’ sun exposed as opposed to sites which are ‘occasionally’ sun exposed and as such they differ in their cumulative ultraviolet (UV) exposure. This study addresses this limitation by investigating the frequency of occurrence of a rarely reported 3895 bp mtDNA deletion in 104 age-matched human skin samples taken from different sun-exposed body sites. There was a significant increase in the deletion frequency with increasing UV exposure (p
ISSN:0022-202X
1523-1747
DOI:10.1111/j.0022-202X.2004.23457.x