Real-time display of artifact-free electroencephalography during functional magnetic resonance imaging and magnetic resonance spectroscopy in an animal model of epilepsy

Simultaneous recording of electroencephalogram (EEG) and functional MRI (fMRI) or MR spectroscopy (MRS) can provide further insight into our understanding of the underlying mechanisms of neurologic disorders. Current technology for simultaneous EEG and MRI recording is limited by extensive postacqui...

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Bibliographic Details
Published in:Magnetic resonance in medicine 2005-02, Vol.53 (2), p.456-464
Main Authors: Mirsattari, Seyed M., Ives, John R., Bihari, Frank, Leung, L. Stan, Menon, Ravi S., Bartha, Robert
Format: Article
Language:English
Subjects:
Algorithms
amplifiers
Animals
Brain Mapping - methods
Computer Systems
Diagnosis, Computer-Assisted - methods
electroencephalography (EEG)
Electroencephalography - methods
epilepsy
Epilepsy - chemically induced
Epilepsy - diagnosis
experimental animal models
functional magnetic resonance imaging (fMRI)
independent component analysis (ICA)
Magnetic Resonance Imaging - methods
magnetic resonance spectroscopy (MRS)
Magnetic Resonance Spectroscopy - methods
Male
Penicillins
Rats
Rats, Sprague-Dawley
Reproducibility of Results
Sensitivity and Specificity
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Summary:Simultaneous recording of electroencephalogram (EEG) and functional MRI (fMRI) or MR spectroscopy (MRS) can provide further insight into our understanding of the underlying mechanisms of neurologic disorders. Current technology for simultaneous EEG and MRI recording is limited by extensive postacquisition processing of the data. Real‐time display of artifact‐free EEG recording during fMRI/MRS studies is essential in studies that involve epilepsy to ensure that they address specific EEG features such as epileptic spikes or seizures. By optimizing the EEG recording equipment to maximize the common mode rejection ratio of its amplifiers, a unique EEG system was designed and tested that allowed real‐time display of the artifact‐free EEG during fMRI/MRS in an animal model of epilepsy. Spike recordings were optimized by suppression of the background EEG activity using fast‐acting and easily controlled inhalational anesthesia. Artifact suppression efficiency of 70–100% was achieved following direct subtraction of referentially recorded filtered EEG tracings from active electrodes, which were located in close proximity to each other (over homologous occipital cortices) and a reference electrode. Two independent postacquisition processing tools, independent component analysis and direct subtraction of unfiltered digital EEG data in MATLAB, were used to verify the accuracy of real‐time EEG display. Magn Reson Med 53:456–464, 2005. © 2005 Wiley‐Liss, Inc.
ISSN:0740-3194
1522-2594
DOI:10.1002/mrm.20357