Effect of Prereperfusion Ephedrine on Postreperfusion Syndrome and Graft Function in Living Donor Liver Transplantation

A characteristic pattern of hemodynamic changes that may occur after reperfusion during liver transplantation (LT) is known as postreperfusion syndrome (PRS). We investigated the effect of prophylactic ephedrine administration on PRS and postoperative laboratory results in living donor LT. The medic...

Full description

Saved in:
Bibliographic Details
Published in:Transplantation proceedings 2017-10, Vol.49 (8), p.1815-1819
Main Authors: Chung, I.S., Jee, H.S., Han, S., Ko, J.S., Gwak, M.S., Choi, S.J., Kim, G.S., Lee, S.-K.
Format: Article
Language:English
Subjects:
Adult
Ephedrine - therapeutic use
Female
Hemodynamics
Humans
Incidence
Liver Diseases - complications
Liver Diseases - physiopathology
Liver Diseases - surgery
Liver Transplantation - adverse effects
Living Donors
Male
Middle Aged
Premedication
Prospective Studies
Reperfusion Injury - epidemiology
Reperfusion Injury - prevention & control
Retrospective Studies
Syndrome
Vasoconstrictor Agents - therapeutic use
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A characteristic pattern of hemodynamic changes that may occur after reperfusion during liver transplantation (LT) is known as postreperfusion syndrome (PRS). We investigated the effect of prophylactic ephedrine administration on PRS and postoperative laboratory results in living donor LT. The medical records of adult recipients who underwent living donor LT were reviewed. A total of 308 recipients were divided into the prophylaxis group and the nonprophylaxis group. Graft factors, preoperative and intraoperative recipient factors, and postoperative laboratory results were compared between the 2 groups. Graft factors and preoperative and intraoperative recipient factors did not differ between the 2 groups, except the prevalence of diabetes mellitus and etiology of liver disease. After reperfusion, PRS occurred more frequently (43.2% vs 25.0%; P = .006), and mean arterial pressure was more reduced compared with prereperfusion values (33.7 ± 15.8% vs 22.3 ± 23.5%; P < .001) in the nonprophylaxis group than the prophylaxis group. Postoperative laboratory results did not differ between the 2 groups. In conclusion, prereperfusion administration of ephedrine reduced the incidence and severity of PRS. Further prospective studies on the relationship between prophylactic medication and posttransplantation outcomes are needed. •Because postreperfusion syndrome can result in a negative postoperative outcome, there have been some efforts to prevent its occurrence.•This study evaluated the effects of prereperfusion ephedrine administration during living donor liver transplantation.•Prereperfusion ephedrine can reduce the incidence and severity of postreperfusion syndrome, without affecting postoperative graft outcome.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2017.05.009