Bronchoprotective effect of deep inspirations in cough variant asthma: A distinguishing feature in the spectrum of airway disease?

Bronchoprotective effect of deep inspirations in cough variant asthma: A distinguishing feature in the spectrum of airway disease?

•Deep inspirations (DIs) triggered bronchoconstriction in classic asthma.•The bronchoprotective effect of DIs was preserved in cough variant asthma.•DIs prevented gas trapping in cough but normal airway sensitivity.•These conditions may fall along a continuum of airway disorders. To assess the effec...

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Bibliographic Details
Published in:Respiratory physiology & neurobiology 2018-11, Vol.257, p.55-64
Main Authors: Wasilewski, Nastasia V., Fisher, Thomas, Turcotte, Scott E., Fisher, John T., Lougheed, M. Diane
Format: Article
Language:eng
Subjects:
Adult
Asthma
Asthma - physiopathology
Bronchoconstrictor Agents
Bronchoprotection
Chronic Disease
Cough
Cough - physiopathology
Deep inspirations
Female
Humans
Inhalation - physiology
Lung Volume Measurements
Male
Methacholine
Methacholine Chloride
Middle Aged
Spirometry
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Summary:•Deep inspirations (DIs) triggered bronchoconstriction in classic asthma.•The bronchoprotective effect of DIs was preserved in cough variant asthma.•DIs prevented gas trapping in cough but normal airway sensitivity.•These conditions may fall along a continuum of airway disorders. To assess the effect of deep inspirations (DIs) on airway behaviour in individuals with classic asthma (CA), cough variant asthma (CVA), and methacholine (MCh)-induced cough but normal airway sensitivity (COUGH) during bronchoprovocation. Twenty-five adults (18 female; 44.8 ± 12.3 years (Mean ± SD); n = 9 CA, n = 9 CVA, and n = 7 COUGH) completed two single-dose MCh challenges, with and without DIs. Bronchoprotection was assessed by comparing changes in bronchoconstriction (FEV1, FVC, FEV1/FVC, FEF50, FEF25-75), gas trapping (RV, RV/TLC) and impulse oscillometry (IOS) measurements. The% changes in FEV1 with and without DIs were not significantly different within any group. Decreases in FEF50 and FEF25-75 were greater in CA (p = 0.041 and p = 0.029), decreases in FVC (% predicted) and FEV1/FVC(%) were less in CVA (p = 0.048 and p = 0.010), and increases in RV (L) and RV/TLC (% predicted) were less in COUGH (p = 0.007 and p = 0.028), respectively. No differences in IOS measurements were noted. DIs triggered bronchoconstriction in CA, bronchoprotection in CVA, and prevented gas trapping in COUGH.
ISSN:1569-9048
1878-1519