The Italian compassionate use of sofosbuvir in HCV patients waitlisted for liver transplantation: A national real‐life experience

Background & Aims This study aimed to assess the real‐life clinical and virological outcomes of HCV waitlisted patients for liver transplantation (LT) who received sofosbuvir/ribavirin (SOF/R) within the Italian compassionate use program. Methods Clinical and virological data were collected in 2...

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Bibliographic Details
Published in:Liver international 2018-04, Vol.38 (4), p.733-741
Main Authors: Martini, Silvia, Donato, Maria Francesca, Mazzarelli, Chiara, Rendina, Maria, Visco‐Comandini, Ubaldo, Filì, Daniela, Gianstefani, Alice, Fagiuoli, Stefano, Melazzini, Mario, Montilla, Simona, Pani, Luca, Petraglia, Sandra, Russo, Pierluigi, Trotta, Maria Paola, Carrai, Paola, Caraceni, Paolo, Angeli, Paolo, Ballardini, Giorgio, Bernabucci, Veronica, Bhoori, Sherrie, Burra, Patrizia, Civolani, Alberto, D'Offizi, Gianpiero, Felder, Martina, Gaeta, Giovanni Battista, Ganga, Roberto, Ginanni Corradini, Stefano, Iemmolo, Rosa Maria, Lenci, Ilaria, Lionetti, Raffaella, Montalbano, Marzia, Morelli, Maria Cristina, Picciotto, Antonino, Sapere, Cristina, Serviddio, Gaetano, Tamè, Mariarosa, Verucchi, Gabriella, Zignego, Anna Linda
Format: Article
Language:English
Subjects:
Adult
Aged
Antiviral agents
Antiviral Agents - therapeutic use
bridging therapy
Carcinoma, Hepatocellular - drug therapy
Cirrhosis
Compassionate Use Trials
Deactivation
decompensated cirrhosis
delisting
direct‐acting antivirals
Drug Therapy, Combination
Female
Hepacivirus - genetics
hepatitis C
Hepatitis C, Chronic - drug therapy
Hepatocellular carcinoma
Humans
Inactivation
Italy
Kaplan-Meier Estimate
Liver
Liver cirrhosis
Liver Cirrhosis - surgery
Liver Cirrhosis - virology
Liver Neoplasms - surgery
Liver Neoplasms - virology
Liver Transplantation
Male
Middle Aged
Patients
Prospective Studies
Ribavirin
Ribavirin - therapeutic use
Ribonucleic acid
RNA
Sofosbuvir - therapeutic use
Therapy
Transplantation
Transplants & implants
Waiting Lists
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Summary:Background & Aims This study aimed to assess the real‐life clinical and virological outcomes of HCV waitlisted patients for liver transplantation (LT) who received sofosbuvir/ribavirin (SOF/R) within the Italian compassionate use program. Methods Clinical and virological data were collected in 224 patients with decompensated cirrhosis and/or hepatocellular carcinoma (HCC) receiving daily SOF/R until LT or up a maximum of 48 weeks. Results Of 100 transplanted patients, 51 were HCV‐RNA negative for >4 weeks before LT (SVR12: 88%) and 49 negative for
ISSN:1478-3223
1478-3231
DOI:10.1111/liv.13588