Dystonia

Dystonia is a clinically heterogeneous group of hyperkinetic movement disorders. Recent advances have provided a better understanding of these conditions with significant clinical impact. Peer reviewed journals and reviews. PubMed.gov. A recent consensus classification, including the assessment of p...

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Bibliographic Details
Published in:British medical bulletin 2017-09, Vol.123 (1), p.91-102
Main Authors: De Pablo-Fernandez, Eduardo, Warner, Thomas T
Format: Article
Language:English
Subjects:
Consensus
Deep Brain Stimulation
Dystonia - diagnosis
Dystonia - genetics
Dystonia - therapy
Forecasting
Humans
Syndrome
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Summary:Dystonia is a clinically heterogeneous group of hyperkinetic movement disorders. Recent advances have provided a better understanding of these conditions with significant clinical impact. Peer reviewed journals and reviews. PubMed.gov. A recent consensus classification, including the assessment of phenomenology and identification of the dystonia syndromes, has provided a helpful tool for the clinical assessment. New forms of monogenic dystonia have been recently identified. Despite recent advances in the understanding of dystonia, treatment remains symptomatic in most patients. Recent advances in genetics have provided a better understanding of the potential pathogenic mechanisms involved in dystonia. Deep brain stimulation has shown to improve focal and combined forms of dystonia and its indications are constantly expanding. Growing understanding of the disease mechanisms involved will allow the development of targeted and disease-modifying therapies in the future.
ISSN:0007-1420
1471-8391
DOI:10.1093/bmb/ldx019