High-intensity interval training has beneficial effects on cardiac remodeling through local renin-angiotensin system modulation in mice fed high-fat or high-fructose diets

HIIT (high-intensity interval training) has the potential to reduce cardiometabolic risk factors, but the effects on cardiac remodeling and local RAS (renin-angiotensin system) in mice fed high-fat or high-fructose diets still need to be fully addressed. Sixty male C57BL/6 mice (12weeks old) were ra...

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Bibliographic Details
Published in:Life sciences (1973) 2017-11, Vol.189, p.8-17
Main Authors: de Oliveira Sá, Guilherme, dos Santos Neves, Vívian, de Oliveira Fraga, Shyrlei R., Souza-Mello, Vanessa, Barbosa-da-Silva, Sandra
Format: Article
Language:English
Subjects:
ACE2
Angiotensin AT1 receptors
Angiotensin AT2 receptors
Angiotensin I - metabolism
Angiotensin-converting enzyme 2
Animals
Blood pressure
Blood Pressure - physiology
Cardiac remodeling
Diet
Diet, High-Fat
Fructose
Gene expression
Gene Expression Regulation - physiology
Health risks
Heart
Heart diseases
High fat diet
High-fructose diet
High-Intensity Interval Training
HIIT
Hypertension
Hypertension - therapy
Hypertrophy
Hypertrophy, Left Ventricular - therapy
Insulin
Insulin Resistance - physiology
Male
Mice
Mice, Inbred C57BL
Peptide Fragments - metabolism
Peptidyl-dipeptidase A
Peptidyl-Dipeptidase A - metabolism
Proteins
Random Allocation
RAS
Receptor, Angiotensin, Type 2 - metabolism
Renin
Renin - metabolism
Renin-Angiotensin System - physiology
Risk analysis
Risk factors
Rodents
Sensitivity
Sensitivity enhancement
Structure-function relationships
Studies
Subgroups
Training
Ventricle
Ventricular Remodeling - physiology
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Summary:HIIT (high-intensity interval training) has the potential to reduce cardiometabolic risk factors, but the effects on cardiac remodeling and local RAS (renin-angiotensin system) in mice fed high-fat or high-fructose diets still need to be fully addressed. Sixty male C57BL/6 mice (12weeks old) were randomly divided into three groups, control (C), High-fat (HF), or High-fructose diet (HRU) and were monitored for eight weeks before being submitted to the HIIT. Each group was randomly assigned to 2 subgroups, one subgroup was started on a 12-week HIIT protocol (T=trained group), while the other subgroup remained non-exercised (NT=not-trained group). HIIT reduced BM and systolic blood pressure in high-fat groups, while enhanced insulin sensitivity after high-fat or high-fructose intake. Moreover, HIIT reduced left ventricular hypertrophy in HF-T and HFRU-T. Notably, HIIT modulated key factors in the local left ventricular renin-angiotensin-system (RAS): reduced protein expression of renin, ACE (Angiotensin-converting enzyme), and (Angiotensin type 2 receptor) AT2R in HF-T and HFRU-T groups but reduced (Angiotensin type 1 receptor) AT1R protein expression only in the high-fat trained group. HIIT modulated ACE2/Ang (1–7)/Mas receptor axis. ACE2 mRNA gene expression was enhanced in HF-T and HFRU-T groups, complying with elevated Mas (Mas proto-oncogene, G protein-coupled receptor) receptor mRNA gene expression after HIIT. This study shows the effectiveness of HIIT sessions in producing improvements in insulin sensitivity and mitigating LV hypertrophy, though hypertension was controlled only in the high-fat-fed submitted to HIIT protocol. Local RAS system in the heart mediates these findings and receptor MAS seems to play a pivotal role when it comes to the amelioration of cardiac structural and functional remodeling due to HIIT.
ISSN:0024-3205
1879-0631
DOI:10.1016/j.lfs.2017.09.012