Gamma-glutamyltransferase and cardiovascular mortality in Korean adults: A cohort study

Insufficient evidence has been reported on the associations between gamma-glutamyltransferase (GGT) and cardiovascular disease (CVD) mortality from studies with an adequate number of participants. 512,990 Korean adults who participated in routine health examinations during the period 2002–2003 were...

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Bibliographic Details
Published in:Atherosclerosis 2017-10, Vol.265, p.102-109
Main Authors: Yi, Sang-Wook, Lee, Sang-Hun, Hwang, Hee-Jin, Yi, Jee-Jeon
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Asians
Biomarkers - blood
Cardiovascular diseases
Cardiovascular Diseases - blood
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - mortality
Cause of Death
Cohort studies
Comorbidity
Female
Gamma-glutamyltransferase
gamma-Glutamyltransferase - blood
Humans
Ischemic heart disease
Life Style
Male
Middle Aged
Mortality
Odds Ratio
Proportional Hazards Models
Prospective Studies
Republic of Korea - epidemiology
Risk Factors
Stroke
Up-Regulation
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Summary:Insufficient evidence has been reported on the associations between gamma-glutamyltransferase (GGT) and cardiovascular disease (CVD) mortality from studies with an adequate number of participants. 512,990 Korean adults who participated in routine health examinations during the period 2002–2003 were followed up until 2013. Hazard ratios (HRs) were calculated after adjusting for potential confounders. Each 1-unit higher natural-log-transformed GGT (LogeGGT) level was associated with approximately 30–50% higher mortality risk of CVD (HR = 1.31): hypertensive diseases (HR = 1.31), ischemic heart diseases (IHD, HR = 1.29), total stroke (HR = 1.29), acute myocardial infarction (HR = 1.30), chronic IHD (HR = 1.27), heart failure (HR = 1.48), hemorrhagic stroke (HR = 1.42), and ischemic stroke (HR = 1.27). The associations with CVD mortality did not vary by sex, or alcohol use, whereas they were stronger in younger (
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2017.08.028