Tyrosine-derived polycarbonate membrane in treating mandibular bone defects. An experimental study

This study was designed to evaluate the suitability of a novel bioabsorbable material in treating bone defects. A poly(desaminotyrosyl-tyrosine-ethyl ester carbonate) (PDTE carbonate) membrane (thickness 0.2–0.3 mm) was implanted into the mandibular angle of 20 New Zealand White rabbits to cover a t...

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Bibliographic Details
Published in:Journal of the Royal Society interface 2006-10, Vol.3 (10), p.629-635
Main Authors: Asikainen, Antti J, Noponen, Jukka, Lindqvist, Christian, Pelto, Mika, Kellomäki, Minna, Juuti, Hanne, Pihlajamäki, Harri, Suuronen, Riitta
Format: Article
Language:English
Subjects:
Animals
Bioabsorbable Membrane
Biocompatible Materials
Biopolymers - therapeutic use
Bone Regeneration - physiology
Female
Guided Bone Regeneration
Guided Tissue Regeneration - methods
Implants, Experimental
Mandible
Mandibular Diseases - surgery
Membranes, Artificial
poly(desaminotyrosyl-tyrosine-ethyl ester carbonate)
Polycarboxylate Cement - therapeutic use
Rabbit
Rabbits
Reconstruction
Tyrosine - analogs & derivatives
Tyrosine - therapeutic use
Wound Healing - physiology
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Summary:This study was designed to evaluate the suitability of a novel bioabsorbable material in treating bone defects. A poly(desaminotyrosyl-tyrosine-ethyl ester carbonate) (PDTE carbonate) membrane (thickness 0.2–0.3 mm) was implanted into the mandibular angle of 20 New Zealand White rabbits to cover a through-and-through defect (12×6 mm). In group 1, the defects were left unfilled but covered with membrane and in group 2 the defects were filled with bioactive glass mesh and covered with membrane, too. Controls were left uncovered and unfilled. The animals were followed for 6, 12, 24 and 52 weeks, respectively. The material was evaluated by qualitative analysis of histological reactions and newly formed bone.
ISSN:1742-5689
1742-5662
DOI:10.1098/rsif.2006.0119