Visible light photocatalytic decarboxylative monofluoroalkenylation of α-amino acids with gem-difluoroalkenes

α-Amino acids are among the most common biologically active molecules in nature, and their functionalization has attracted much attention. In this communication, a novel, efficient and general visible-light photocatalytic decarboxylative monofluoroalkenylation of N-protected α-amino acids with gem-d...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2017-09, Vol.53 (74), p.10299-10302
Main Authors: Li, Jingjing, Lefebvre, Quentin, Yang, Haijun, Zhao, Yufen, Fu, Hua
Format: Article
Language:English
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Summary:α-Amino acids are among the most common biologically active molecules in nature, and their functionalization has attracted much attention. In this communication, a novel, efficient and general visible-light photocatalytic decarboxylative monofluoroalkenylation of N-protected α-amino acids with gem-difluoroalkenes is reported, affording the corresponding α-amino monofluoroalkenes which might find applications in medical chemistry and materials science. The reaction proceeded at room temperature with high efficiency and tolerance of various functional groups.
ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc05758j